研究方向
我的主要研究目标是逐步解析调控人类棕色脂肪细胞分化与激活的分子机制。我们希望发现能够促进肥胖患者脂肪细胞募集并增强产热的新靶点与通路,最终为开发更有效的代谢疾病治疗方法作出贡献。
背景与经历
2013 年,我在西班牙圣地亚哥德孔波斯特拉大学以荣誉成绩取得生物学学士学位。随后,我于 2014 年在萨拉曼卡大学完成生物学与临床肿瘤学硕士学位,并在同一所大学获得生物科学博士学位。2019 年底,我获得西班牙 Ramon Areces 基金会奖学金资助加入 TVPlab,目前担任 Sir Henry Wellcome 博士后研究员。
代表性论文与成果
- Rodríguez-Fdez, S.*, Lorenzo-Martín, L.F., Fernández-Pisonero, I., Porteiro, B., Veyrat-Durebex, C., Beiroa, D., Al-Massadi, O., Abad, A., Diéguez, C., Coppari, R., Nogueiras, R., and Bustelo, X.R. (2020). Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and glucose homeostasis. Nat Commun 11, 5808 (2020). https://doi.org/10.1038/s41467-020-19489-z
- Lorenzo-Martín, L.F.*, Rodríguez-Fdez, S.*, Fabbiano, S.*, Abad, A., Garcia-Macias, M., Dosil, M., Cuadrado, M., Robles-Valero, J., and Bustelo, X.R. (2020). Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor. Oncogene 39: 5098-5111.
- Rodríguez-Fdez, S.*, Nevado, L.F, Lorenzo-Martín, L.F. and Bustelo, X.R. (2020). Lysine acetylation reshapes the downstream signaling landscape of Vav1 in lymphocytes. Cells 9: 609.
- Rodríguez-Fdez, S.*, Citterio, C., Lorenzo-Martín, L.F., Baltanás-Copado, J., Llorente-González, C., Corbalán-García, S., Vicente-Manzanares, M., and Bustelo, X.R. (2019). Phosphatidylinositol monophosphates regulate optimal Vav1 signaling output. Cells 8: 1649.
- Barreira, M., Rodríguez-Fdez, S.*, and Bustelo, X.R. (2018). New Insights into the Vav1 Activation Cycle in Lymphocytes. Cell Signal 45: 132–144
- Rodríguez-Fdez, S.*, and Bustelo, X.R. (2019). The Vav GEF family: an evolutionary and functional perspective. Cells 8: 465