Vanessa Pellegrinelli 博士

TVPlab · Cambridge

Vanessa Pellegrinelli 博士

British Heart Foundation CRE Career Development Fellow

电子邮箱vp332@medschl.cam.ac.uk

个人简介

研究脂肪组织结构及细胞外基质重塑如何影响组织可塑性与功能，关注纤维炎症和棕色脂肪产热障碍。

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研究方向

我结合模拟病理生理状态的体内和体外模型、成像及系统生物学方法，研究脂肪组织可塑性受损如何影响组织功能。

背景与经历

我是一名 Research Associate，研究脂肪组织结构网络的不同方面，包括细胞外基质重塑。我具有整合生理学背景，在脂肪组织生物学和动物表型研究方面积累了丰富经验。我工作负责、勤勉、组织能力强，注重解决问题，能够迅速适应多元文化环境，并始终致力于科学合作。

代表性论文与成果

  1. Pellegrinelli, V., Figueroa-Juarez, E., Samuelson, I., U-Din, M., Rodriguez-Fdez, S., Virtue, S., Leggat, J., Cubuk, C., Peirce, V.J., Niemi, T. and Campbell, M., 2023. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Reports, 42(6).
  2. Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J.M., Bidault, G., Vázquez-Borrego, M.C., Dias, A.R. and Pucker, B., 2022. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nature metabolism, 4(4), pp.476-494.
  3. Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Horton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal-Puig A. Nat Commun, 2018.
  4. Pellegrinelli V, Rouault C, Rodriguez-Cuenca S, Albert V, Edom-Vovard F, Vidal-Puig A, Clément K, Butler-Browne G, Lacasa D. Human adipocytes induce inflammation and atrophy in muscle cells during obesity. Diabetes, 2015.
  5. Pellegrinelli V, Heuvingh J, du Roure O, Rouault C, Devulder A, Klein C, Lacasa M, Clément E, Lacasa D, Clément K. Human adipocyte function is impacted by mechanical cues.J Pathol, 2014.
  6. Pellegrinelli V, Rouault C, Veyrie N, Clément K and Lacasa D.Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions In A 3D Setting: Partial Rescue By Angiopoietin-1. Diabetes, 2014.
  7. Lacasa D, Pellegrinelli V, Keophiphath M, Clement K. International patent UPMC N°PCT/IB2011/O52241, WO2011148310-A1; FR2960549-A1; AU2011259756-A1; CA2800667-A1; EP2576770-A1; CN102985533-A; JP2013526291-W; US2013183706-A1.« Culture procedure of human mature adipocytes »