Mark Campbell

背景与经历

我的岗位主要负责小鼠代谢及／或心脏代谢表型研究项目的科学与运营管理。这包括持续评估和优化团队开展研究所需的财务、技术及人员资源，以确保研究按照适当的时间安排和既定预算目标推进。

通过运用和传播科学证据、适当的衡量指标、关键绩效指标、知识与经验，我的工作涉及识别并减少流程中的问题，以改善工作流程和生产效率，确保采用最佳实践、最大程度提升研究质量，并最终监督和增强团队的科研产出能力。

具体研究兴趣

在肥胖、糖尿病和非酒精性脂肪性肝病背景下，我主要关注：

• 小鼠代谢表型的特征鉴定
• 脂肪组织生物学
• 线粒体功能障碍

代表性论文与成果

1. Pellegrinelli, V., Figueroa-Juarez, E., Samuelson, I., U-Din, M., Rodriguez-Fdez, S., Virtue, S., Leggat, J., Cubuk, C., Peirce, V.J., Niemi, T. and Campbell, M., 2023. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Reports, 42(6).
2. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. V Pellegrinelli, S Rodriguez-Cuenca, C Rouault, E Figueroa-Juarez, H Schilbert, S Virtue, JM Moreno-Navarrete, G Bidault, MC Vázquez Borrego, AR Dias, B. Pucker, M Dale, M Campbell, S Carobbio, YH Lin, M. Vacca, J Aron-Wisnewsky, S Mora, MM Masiero, A Emmanouilidou, S Mukhopadhyay, G Dougan, M den Hoed, R JF Loos, JM Fernández-Real, D Chiarugi, K Clément, A Vidal-Puig. Nature Metabolism 2022;4(4):476-494.
3. Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects. Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G3, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Oresic M, Bjursell M, Bohlooly-Y M, Lindén D and Vidal-Puig, A. FASEB J. 2021 Sep;35(9):e21752.
4. Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates. Diabetes Obes Metab. 2018
5. Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Prog Lipid Res. 2017