Guillaume Bidault 博士

TVPlab · Cambridge

Guillaume Bidault 博士

博士后研究员

电子邮箱gb483@medschl.cam.ac.uk

个人简介

研究巨噬细胞的脂质合成与重塑如何调控炎症，以及这些免疫细胞过程如何参与肥胖的心脏代谢并发症。

了解研究方向 返回团队成员

背景与经历

我是一名于 2013 年加入 TVP Lab 的博士后研究员，尤其关注免疫系统与巨噬细胞在肥胖相关心脏代谢并发症形成中的作用。我的研究重点是脂质生物合成与重塑，旨在阐明巨噬细胞内在的脂质代谢如何调节肥胖中的炎症。

具体研究兴趣

代谢、免疫学、巨噬细胞、脂质、肥胖和心血管疾病。

代表性论文与成果

  1. Bidault G, Garcia M, Capeau J, Morichon R, Vigouroux C, Béréziat V. Progerin expression induces inflammation, oxidative stress and senescence in human coronary endothelial cells. Cells. 2020 May 12;9(5):1201. doi: 10.3390/cells9051201. PMID: 32408587
  2. Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity. Elife. 2019 Aug 16;8. pii: e47990. doi: 10.7554/eLife.47990. PubMed PMID: 31418690; PubMed Central PMCID: PMC6748830.
  3. Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PubMed PMID: 30814564; PubMed Central PMCID: PMC6393541.
  4. Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Horton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal-Puig A. Adipocyte-secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue. Nat Commun. 2018 Nov 26;9(1):4974. doi: 10.1038/s41467-018-07453-x. PubMed PMID: 30478315; PubMed Central PMCID: PMC6255810.
  5. Vigouroux C, Guénantin AC, Vatier C, Capel E, Le Dour C, Afonso P, Bidault G, Béréziat V, Lascols O, Capeau J, Briand N, Jéru I. Lipodystrophic syndromes due to LMNA mutations: recent developments on biomolecular aspects, pathophysiological hypotheses and therapeutic perspectives. Nucleus. 2018 Jan 1;9(1):235-248. doi: 10.1080/19491034.2018.1456217. Review. PubMed PMID: 29578370; PubMed Central PMCID: PMC5973242.
  6. Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D. Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review. Adv Nutr. 2017 Sep 15;8(5):694-704. doi: 10.3945/an.117.015792. Print 2017 Sep. Review. PubMed PMID: 28916570; PubMed Central PMCID: PMC5593103.
  7. Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D. Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function. Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700074. Epub 2017 Apr 12. PubMed PMID: 28276197.
  8. Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004. Epub 2015 Nov 25. PubMed PMID: 26628376; PubMed Central PMCID: PMC4688035.
  9. Guénantin AC, Briand N, Bidault G, Afonso P, Béréziat V, Vatier C, Lascols O, Caron-Debarle M, Capeau J, Vigouroux C. Nuclear envelope-related lipodystrophies. Semin Cell Dev Biol. 2014 May;29:148-57. doi: 10.1016/j.semcdb.2013.12.015. Epub 2013 Dec 30. Review. PubMed PMID: 24384368.
  10. Vatier C, Bidault G, Briand N, Guénantin AC, Teyssières L, Lascols O, Capeau J, Vigouroux C. What the genetics of lipodystrophy can teach us about insulin resistance and diabetes. Curr Diab Rep. 2013 Dec;13(6):757-67. doi: 10.1007/s11892-013-0431-7. Review. PubMed PMID: 24026869.
  11. Bidault G, Garcia M, Vantyghem MC, Ducluzeau PH, Morichon R, Thiyagarajah K, Moritz S, Capeau J, Vigouroux C, Béréziat V. Lipodystrophy-linked LMNA p.R482W mutation induces clinical early atherosclerosis and in vitro endothelial dysfunction. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2162-71. doi: 10.1161/ATVBAHA.113.301933. Epub 2013 Jul 11. PubMed PMID: 23846499.
  12. Bidault G, Vatier C, Capeau J, Vigouroux C, Béréziat V. LMNA-linked lipodystrophies: from altered fat distribution to cellular alterations. Biochem Soc Trans. 2011 Dec;39(6):1752-7. doi: 10.1042/BST20110675. Review. PubMed PMID: 22103520.