DR. Renata Risi


About me

I graduated from the medical school in 2017 and I am completing my specialization training in Endocrinology and Metabolic Diseases at Policlinico Umberto I, University of Rome “La Sapienza”, Italy. During my medical education, I have been trained on the management of endocrinological diseases, and I have developed a special interest on metabolic syndrome, obesity, and diabetes mellitus.

Research Interests

​During my specialization training, my research interest has focused on the treatment of metabolically unhealthy obesity and non-alcoholic fatty liver disease, and in particular on the metabolic effects of nutritional ketosis. In the TVP lab, I am studying how human immune cells handle pro-inflammatory lipid challenges and to what extent this process can predict the development of obesity-related complications. My ultimate goal is to identify subjects at higher risk among patients suffering from obesity.


Watanabe M, Risi R, Camajani E, et al. Baseline homa IR and circulating FGF21 levels predict NAFLD improvement in patients undergoing a low carbohydrate dietary intervention for weight loss: A prospective observational pilot study. Nutrients. 2020;12(7):1-13. doi:10.3390/nu12072141

Watanabe M, Tozzi R, Risi R, et al. Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature. Obes Rev. 2020;21(8). doi:10.1111/obr.13024

Watanabe M, Singhal G, Fisher FM, et al. (among authors: Risi R) Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis. Endocrine. 2020;67(1):95- 108. doi:10.1007/s12020-019-02124-3

Watanabe M, Risi R, De Giorgi F, et al. Obesity treatment within the Italian national healthcare system tertiary care centers: what can we learn? Eat Weight Disord. 2020. doi:10.1007/s40519- 020-00936-1

Basciani S, Camajani E, Contini S, et al. (among authors: Risi R) Very-low-calorie ketogenic diets with whey, vegetable, or animal protein in patients with obesity: A randomized pilot study. J Clin Endocrinol Metab. 2020;105(9):1-11. doi:10.1210/clinem/dgaa336

Watanabe M, Caruso D, Tuccinardi D, et al. (among authors: Risi R) Visceral fat shows the strongest association with the need of intensive Care in Patients with COVID-19. Metabolism. 2020:154319. doi:10.1016/j.metabol.2020.154319

Watanabe M, Risi R, Masi D, et al. Current evidence to propose different food supplements for weight loss: A comprehensive review. Nutrients. 2020;12(9):1-43. doi:10.3390/nu12092873

Risi R, Tuccinardi D, Mariani S, et al. Liver disease in obesity and underweight: the two sides of the coin. A narrative review. Eat Weight Disord. 2020 Nov 4. doi: 10.1007/s40519-020- 01060-w.

Risi R, Masieri, S, Poggiogalle E, et al. Nickel Sensitivity Is Associated with GH-IGF1 Axis Impairment and Pituitary Abnormalities on MRI in Overweight and Obese Subjects. Int. J. Mol. Sci. 2020, 21, 9733

Watanabe M, Balena A, Tuccinardi D, et al. (among authors: Risi R)  Central obesity, smoking habit, and hypertension are associated with lower antibody titres in response to COVID-19 mRNA vaccine. Diabetes Metab Res Rev. 2021;10.1002/dmrr.3465.