Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function

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Mol Metab. 2021 Mar 24:101220. doi: 10.1016/j.molmet.2021.101220. Online ahead of print.PMID: 33774223 Free article.

Kasparas Petkevicius 1, Guillaume Bidault 2, Sam Virtue 2, Stephen A Newland 3, Martin Dale 2, Aurelien Dugourd 4, Julio Saez-Rodriguez 4, Ziad Mallat 3, Antonio Vidal-Puig 5

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Suppression of insulin-induced gene 1(INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.

Mol Metab. 2021 Mar 12:101210. doi: 10.1016/j.molmet.2021.101210. Online ahead of print.PMID: 33722690 Free article.

Vian Azzu 1, Michele Vacca 2, Ioannis Kamzolas 3, Zoe Hall 4, Jack Leslie 5, Stefania Carobbio 6, Sam Virtue 6, Susan E Davies 7, Agnes Lukasik 6, Martin Dale 6, Mohammad Bohlooly-Y 8, Animesh Acharjee 9, Daniel Lindén 10, Guillaume Bidault 6, Evangelia Petsalaki 11, Julian L Griffin 4, Fiona Oakley 5, Michael Ed Allison 12, Antonio Vidal-Puig 13

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Unraveling the developmental roadmap toward human brown adipose tissue​

Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A.Stem Cell Reports. 2021 Apr 13;16(4):1010. doi: 10.1016/j.stemcr.2021.03.009.PMID: 33852883 Free PMC article. 

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Obesity and pregnancy, the perfect metabolic storm.

Corrales P, Vidal-Puig A, Medina-Gómez G.Eur J Clin Nutr. 2021 Apr 28. doi: 10.1038/s41430-021-00914-5. Online ahead of print.PMID: 33911209 

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Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women.

Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR.Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. Online ahead of print.PMID: 33858825

 

Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.

Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M.Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x.PMID: 33833312 Free PMC article.

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Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.

Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL.Hepatology. 2021 Mar;73(3):1028-1044. doi: 10.1002/hep.31391. Epub 2020 Nov 3.PMID: 32460431

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Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.

Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD.Nat Commun. 2021 Mar 26;12(1):1905. doi: 10.1038/s41467-021-22272-3.PMID: 33772024 Free article.

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Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.

Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22.PMID: 33619380

 

Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family.

Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21.PMID: 33520119

 

Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.

Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A.FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R.PMID: 33484195

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Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family.

Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21.PMID: 33520119 

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2020

GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25.PMID: 31875646 

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Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.

Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL.Hepatology. 2020 May 27. doi: 10.1002/hep.31391. Online ahead of print.PMID: 32460431

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Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.

Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C.Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. Epub 2019 Oct 31.PMID: 31918923 

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Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.

Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM.Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448.PMID: 33268509

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Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease.

Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A.Gastroenterology. 2020 May;158(7):1899-1912. doi: 10.1053/j.gastro.2019.12.054. Epub 2020 Feb 13.PMID: 32061598

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Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.Nature. 2020 Feb;578(7796):E24. doi: 10.1038/s41586-020-2031-4.PMID: 32051582

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Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.

Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A.Nat Metab. 2020 Jun;2(6):514-531. doi: 10.1038/s42255-020-0214-9. Epub 2020 Jun 8.PMID: 32694734

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Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.

Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, Schcolnik-Cabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R, Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR.Metabolism. 2020 Feb;103:154048. doi: 10.1016/j.metabol.2019.154048. Epub 2019 Dec 13.PMID: 31843339

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Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.

Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA.BMJ Open Diabetes Res Care. 2020 Jan;8(1):e000945. doi: 10.1136/bmjdrc-2019-000945.PMID: 32049633

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Studying Brown Adipose Tissue in a Human in vitro Context.

Samuelson I, Vidal-Puig A.Front Endocrinol (Lausanne). 2020 Sep 15;11:629. doi: 10.3389/fendo.2020.00629. eCollection 2020.PMID: 33042008 

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Reply to: 'Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells'.

Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Shabeer M, Shyong Tai E, Vidal-Puig A, Toh SA.Sci Rep. 2020 Jun 15;10(1):9634. doi: 10.1038/s41598-020-64706-w.PMID: 32541770 

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Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.

Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M.PLoS Genet. 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. eCollection 2020 Oct.PMID: 33057429 Free PMC article.

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The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production.

Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR.Sci Adv. 2020 Nov 25;6(48):eabd3139. doi: 10.1126/sciadv.abd3139. Print 2020 Nov.PMID: 33239297 Free PMC article.

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Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.

Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O'Rahilly S, Semple RK.Mol Metab. 2020 Oct;40:101020. doi: 10.1016/j.molmet.2020.101020. Epub 2020 May 19.PMID: 32439336 Free PMC article.

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Publisher Correction: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.

Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC.Nat Commun. 2020 Feb 21;11(1):1078. doi: 10.1038/s41467-020-14939-0.PMID: 32081871 Free PMC article.

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2019

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Interaction between Hormone-Sensitive Lipase and ChREBP in Fat Cells Controls Insulin Sensitivity.

Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud PD, Tavernier G, Caspar-Bauguil S,. Virtue S, Sramkova V, Monbrun L, Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Roffarello BM, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Michel JB, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris WHM, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D.. Nature Metab 2019 1, 122-146. doi: 10.1038/s42255-018-0007-6.

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Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.

Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C. Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. PubMed PMID: 31918929.

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GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S. Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1911-y. [Epub ahead of print] Erratum in: Nature. 2020 Feb 13; PubMed PMID: 31875646.

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4-Methylumbelliferone improvesthe thermogenic capacity of brown adipose tissue.

Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW. Nat Metab. 2019 May;1(5):546-559. doi: 10.1038/s42255-019-0055-6. Epub 2019 Apr 22. PubMed PMID: 31602424.

 

Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.

Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T. Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PubMed PMID: 31509948.

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Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.

Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8. pii: e47990. doi: 10.7554/eLife.47990. PubMed PMID: 31418690; PubMed Central PMCID: PMC6748830.

 

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.

Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ. J Exp Med. 2019 Sep 2;216(9):1999-2009. doi:10.1084/jem.20190689. Epub 2019 Jun 27. PubMed PMID: 31248899; PubMed Central PMCID: PMC6719433.

 

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption.

Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J. Cell Rep. 2019 Jun 11;27(11):3385-3400.e3.doi: 10.1016/j.celrep.2019.05.054. PubMed PMID: 31189119.
 

Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.

Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM. FASEB J. 2019 Aug;33(8):9656-9671. doi: 10.1096/fj.201900479R. PubMed PMID: 31145872.

 

Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge.

Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA. Frontiers in endocrinology (Lausanne). 2019 Apr 24 ; 10:256. doi: 10.3389/fendo.2019.00256. eCollection 2019. PMID: 31068904

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Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.

Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC. Nature Communication. 2019 Apr 4;10(1):1546. doi: 10.1038/s41467-019-09514-1.PMID:30948720

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Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.

Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ. Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PMID: 30814564

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Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes, and regulates triglyceride accumulation and insulin sensitivity in adipocytes.

Agrawal M, Yeo CR, Shabbir A, Chhay V, Silver DL, Magkos F, Vidal-Puig A, Toh SA. FASEB J. 2019 Jan;33(1):430-440. doi: 10.1096/fj.201701321RR.

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GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism.

Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM. J Steroid Biochem Mol Biol. 2019 Jan;185:256-267. doi: 10.1016/j.jsbmb.2018.09.013.

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GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S. Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi:10.1016/j.cmet.2018.12.016.

 

Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.

Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ. Mol Metab. 2019 Feb;20:38-50. doi: 10.1016/j.molmet.2018.11.010.

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2018

Adipocyte secreted BMP8b mediates adrenergic-induced remodeling of the neuro-vascular network in adipose tissue.

Pellegrinelli V, Peirce VI, Howard L, Virtue S, Turei D, Senzacqua M, FrontiniA , Dalley JW, AR Horton AR, Bidault G, SeveriI, Whittle A, Saez-Rodriguez J, Cinti S Davie AM and A Vidal-Puig Nat Comm 2018 Nov 26;9(1):4974. doi: 10.1038/s41467-018-07453-x.

 

Calcium channel CaV2.3 subunits regulate hepatic glucose production by modulating leptin-induced excitation of arcuate pro-opiomelanocortin neurons.

Smith MA, Katsouri L, Virtue S, Vidal-Puig  A, Ashford MLJ, Withers Dj. Cell Reports 2018 Oct 9;25(2):278-287.e4. doi: 10.1016/j.celrep.2018.09.024.

 

Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue.

Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado  E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding K, Vidal-Puig A, Medina-Gomez  G, ArnerP, Rydén M. Cell Reports 2018 Oct 16;25(3):551-560.e5. doi: 10.1016/j.celrep.2018.09.069.

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Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility.

Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A. Cell Rep. 2018 Aug 21;24(8):2005-2012.e7. doi: 10.1016/j.celrep.2018.07.063. PMID:30134163

 

Dietary stearic acid regulates mitochondria in vivo in humans.

Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA. Nat Commun. 2018 Aug 7;9(1):3129. doi: 10.1038/s41467-018-05614-6. PMID:30087348

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Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption.

Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL. Genome Biol. 2018 Jun 20;19(1):79. doi: 10.1186/s13059-018-1439-8. PMID:29925420.

 

P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates.

Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A. Diabetes Obes Metab. 2018 Oct;20(10):2339-2350. doi: 10.1111/dom.13370. PMID: 29790245.

 

Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice.

Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB. Mol Metab. 2018 Jul;13:24-29. doi: 10.1016/j.molmet.2018.05.006. PMID: 29789270.

 

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Corrigendum: Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525e.

 

Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues.

Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, Ruiz-Ponce M, Jiménez-Gómez Y, Ruiz-Limón P, Pérez-Sánchez C, Ábalos-Aguilera MC, Cecchi I, Ortega R, Calvo J, Guzmán-Ruiz R, Malagón MM, Collantes-Estevez E, Vidal-Puig A, López-Pedrera C, Barbarroja N. Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues. J Intern Med. 2018 Jul;284(1):61-77. doi: 10.1111/joim.12743.

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2017

No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men.

Langeveld M, Tan CY, Soeters MR, Virtue S, Watson LP, Murgatroyd PR, Ambler GK, Vidal-Puig S, Chatterjee KV, Vidal-Puig A. Am J Clin Nutr. 2017 Nov;106(5):1197-1205. doi: 10.3945/ajcn.116.148395.

 

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance.

Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M. Cell Metab. 2017 Jul 5;26(1):212-229.e12. doi: 10.1016/j.cmet.2017.06.014.

 

SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes.

Chia Rou Yeo, Madhur Agrawal, Shawn Hoon, Asim Shabbir, Manu Kunaal Shrivastava, Shiqi Huang, Chin Meng Khoo, Vanna Chhay, M. Shabeer Yassin, E. Shyong Tai, Antonio Vidal-Puig & Sue-Anne Toh. Sci Rep 2017 Jun 22;7(1):4031. doi: 10.1038/s41598-017-04369-2.

 

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice.

Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C. Elife. 2017 May 23;6. pii: e22848. doi: 10.7554/eLife.22848. PMID:28532548

 

Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function.

Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D. Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700074.

 

Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme Ain Mammalian Cells.

Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I. Biochem J. 2017 Jul 11;474(14):2489-2508. doi: 10.1042/BCJ20170129.

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Lipid zonation and phospholipid remodeling in non-alcoholic fatty liver disease. Hepatology.

Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL. 2017 Apr;65(4):1165-1180. doi: 10.1002/hep.28953. 

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2016

Meal rich in carbohydrate, but not protein or fat, reveals adverse immunometabolic responses associated with obesity.

Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Nutr J. 2016 Dec 1;15(1):100.

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Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility.

Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA. Nutr Metab (Lond). 2016 Oct 27;13:74

 

Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes.

Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M. PLoS One. 2016 Sep 15;11(9):e0162047. doi: 10.1371/journal.pone.0162047.

 

Assessment of plasma acylcarnitines before and after weight loss in obese subjects.

Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR. Arch Biochem Biophys. 2016 Jul 19;606:73-80. doi: 10.1016/j.abb.2016.07.013.

 

Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness.

Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S. Nat Med. 2016 Jul;22(7):771-9. doi: 10.1038/nm.4115.

 

Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome.

Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM. PLoS Genet. 2016 Mar 10;12(3):e1005916. doi: 10.1371/journal.pgen.1005916.

 

Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice. Stress.

Sanghez V, Cubuk C, Sebastián-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A. 2016 Mar 7:1-11.

 

Mitochondria are required for pro-ageing features of the senescent phenotype.

Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. EMBO J. 2016 Feb 4. pii: e201592862

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2015

Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis.

Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A. Mol Metab.  2015 Nov 11;5(1):19-33. doi: 10.1016/j.molmet.2015.10.005.

 

Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance.

Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A. Sci Rep. 2015 Dec 17;5:18366. doi: 10.1038/srep18366.

 

Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6.

Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A. Cell Rep. 2015 Dec 15;13(10):2039-47. doi: 10.1016/j.celrep.2015.11.004.

 

Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.

Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T. Sci Rep. 2015 Nov 30;5:17565. doi: 10.1038/srep17565.

 

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.

Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H. Nat Commun. 2015 Nov 20;6:8951. doi: 10.1038/ncomms9951.

 

Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.

Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13850-5. doi: 10.1073/pnas.1516004112.

 

Regulation of mitochondrial morphology and function by stearoylation of TFR1.

Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA. Nature 2015 Sep 3;525(7567):124-8. doi: 10.1038/nature14601

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Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation.

Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM. Diabetologia. 2015 Oct;58(10):2424-34. doi: 10.1007/s00125-015-3692-7.

 

Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behaviour in Mice.

Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ. Cell Rep. 2015 Apr 21;11(3):335-43. doi: 10.1016/j.celrep.2015.03.029.

 

Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.

Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A. Int J Obes (Lond). 2015 Jul;39(7):1151-60. doi: 10.1038/ijo.2015.34

 

Human adipocytes induce inflammation and atrophy in muscle cells during obesity. Diabetes.

Pellegrinelli V, Rouault C, Rodriguez-Cuenca S, Albert V, Edom-Vovard F, Vidal-Puig A, Clément K, Butler-Browne G, Lacasa D. 2015 Feb 18. pii: db140796.

 

Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation.

Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):506-11.

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Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression.

Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM. J Mol Med (Berl). 2015 Jan;93(1):83-92.

2014

Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.

Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G, Pagani L, Lawson DJ, Antão T, Vicente M, Mitt M, DeGiorgio M, Faltyskova Z, Xue Y, Ayub Q, Szpak M, Mägi R, Eriksson A, Manica A, Raghavan M, Rasmussen M, Rasmussen S, Willerslev E, Vidal-Puig A, Tyler-Smith C, Villems R, Nielsen R, Metspalu M, Malyarchuk B, Derenko M, Kivisild T. A Am J Hum Genet. 2014 Oct 23;95(5):584-589.

 

Increased dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function.

Barbarroja N, Rodriguez-Cuenca S, Nygren H, Camargo A, Pirraco A, Relat J, Cuadrado I, Pellegrinelli V, Medina-Gomez G, Lopez-Pedrera C, Tinahones FJ, Symons JD, Summers SA, Oresic M, Vidal-Puig A. Diabetes. 2014 Oct 28. pii: DB_140359.

 

DLK1/PREF1 regulates nutrient metabolism and protects from steatosis.

Charalambous M, Da Rocha ST, Radford EJ, Medina-Gomez G, Curran S, Pinnock SB, Ferrón SR, Vidal-Puig A, Ferguson-Smith AC. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16088-93.

 

Understanding disease mechanisms with models of signaling pathway activities.

Sebastian-Leon P, Vidal E, Minguez P, Conesa A, Tarazona S, Amadoz A, Armero C, Salavert F, Vidal-Puig A, Montaner D, Dopazo J. BMC Syst Biol. 2014 Oct 25;8(1):121.

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Response to letter regarding article, “Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with high-risk plaques in human”.

Yu, E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JJ, Hurtst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Circulation 2014 Mar 25;129(12):e408. Doi: 10.1161/CIRCULATIONHA. 112.008032.

 

Methods for performing lipidomics in white adipose tissue.

Roberts LD, West JA, Vidal-Puig A, Griffin JL. Methods Enzymol. 2014;538:211-31. doi: 10.1016/B978-0-12-800280-3.00012-8. 

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Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge.

Paniagua JA, Escandell-Morales JM, Gil-Contreras D, Berral de la Rosa FJ, Romero-Jimenez M, Gómez-Urbano A, Sanchez-Lopez A, Bellido E, Poyato A, Calatayud B, Vidal-Puig AJ. Nutrition. 2014 Feb;30(2):177-85.

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2013

Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome.

Sanghez V, Razzoli M, Carobbio S, Campbell M, McCallum J, Cero C, Ceresini G, Cabassi A, Govoni P, Franceschini P, de Santis V, Gurney A, Ninkovic I, Parmigiani S, Palanza P, Vidal-Puig A, Bartolomucci A. Psychoneuroendocrinology 2013 Sep 2. pii: S0306-4530(13)00287-4.

 

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction.

Moreno-Navarrete JM, Escoté X, Ortega F, Serino M, Campbell M, Michalski MC, Laville M, Xifra G, Luche E, Domingo P, Sabater M, Pardo G, Waget A, Salvador J, Giralt M, Rodriguez-Hermosa JI, Camps M, Kolditz CI, Viguerie N, Galitzky J, Decaunes P, Ricart W, Frühbeck G, Villarroya F, Mingrone G, Langin D, Zorzano A, Vidal H, Vendrell J, Burcelin R, Vidal-Puig A, Fernández-Real JM. Diabetologia 2013 Nov;56(11):2524-37

 

Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A. Diabetes 2013 Aug 6.

 

Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR. Circulation 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10

 

Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis.

Camacho A, Huang JK, Delint-Ramirez I, Yew Tan C, Fuller M, Lelliott CJ, Vidal-Puig A, Franklin RJ. Eur J Neurosci 2013 Jun 14. doi: 10.1111/ejn.12281. [Epub ahead of print].

 

Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men.

Alligier M, Gabert L, Meugnier E, Lambert-Porcheron S, Chanseaume E, Pilleul F, Debard C, Sauvinet V, Morio B, Vidal-Puig A, Vidal H, Laville M. J Clin Endocrinol Metab 2013 Feb;98(2):802-10 (2013)

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2012

Below Thermoneutrality, Changes in Activity Do Not Drive Changes in Total Daily Energy Expenditure between Groups of Mice.

Virtue S, Even P, Vidal-Puig A. Cell Metab Nov 7;16(5):665-71 (2012)

 

Identification of Novel Type 2 Diabetes Candidate Genes Involved in the Crosstalk between the Mitochondrial and the Insulin Signaling Systems.

Mercader JM, Puiggros M, Segrè AV, Planet E, Sorianello E, Sebastian D, Rodriguez-Cuenca S, Ribas V, Bonàs-Guarch S, Draghici S, Yang C, Mora S, Vidal-Puig A, Dupuis J; DIAGRAM Consortium, Florez JC; MITIN Consortium, Zorzano A, Torrents D. PLoS Genet 2012 Dec;8(12):e1003046.

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A new role for Lipocalin Prostaglandin D Synthase in the regulation of brown adipose tissue substrate utilisation.

Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C,  Burling K, Campbell M, Eguchi N,  Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A. Diabetes 61(12):3139-47 (2012).

 

Bartolomucci A, Parmigiani S, Rodgers RJ, Vidal-Puig A, Allan SE, Siegel V. The Obese Species: a special issue on obesity and metabolic disorders. Dis Model Mech 2012 Sep;5(5):563-4.

 

Lipocalin Prostaglandin D Synthase and PPARγ2 Coordinate to Regulate Carbohydrate and Lipid Metabolism In Vivo.

Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A. PLoS One 7(7):e39512. (2012)

 

Ablation of PGC1 beta prevents mTOR dependent endoplasmic Reticulum Stress response.

Camacho A, Rodriguez-Cuenca C, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Antonio Vidal-Puig. Experimental Neurology 237(2):396-406 (2012)

 

PGC-1α Negatively Regulates Extrasynaptic NMDAR Activity and Excitotoxicity.

Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE. J Neurosci. 2012 May 16;32(20):6995-7000.

 

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions.

Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vázquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, Dale M, Virtue S, Villarroya F, Cannon B, Rahmouni K, López M, Vidal-Puig A. Cell. 2012 May 11;149(4):871-85.

 

Increasing Circulating IGFBP1 Levels Improves Insulin Sensitivity, Promotes Nitric Oxide Production, Lowers Blood Pressure, and Protects Against Atherosclerosis.

Rajwani A, Ezzat V, Smith J, Yuldasheva NY, Duncan ER, Gage M, Cubbon RM, Kahn MB, Imrie H, Abbas A, Viswambharan H, Aziz A, Sukumar P, Vidal-Puig A, Sethi JK, Xuan S, Shah AM, Grant PJ, Porter KE, Kearney MT, Wheatcroft SB. Diabetes. 2012 Feb 22.

 

Prediction of Weight Loss and Regain Following Dietary, Lifestyle, and Pharmacologic Intervention.

Napolitano A, Miller SR, Murgatroyd PR, Delafont B, Brooke A, Elkhawad M, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ. Clin Pharmacol Ther. 2012 Feb 15.

 

Ablation of Pparg2 impairs lipolysis and reveals murine strain differences in lipolytic responses.

Rodriguez-Cuenca S, Carobbio S, Vidal-Puig A. FASEB J. 2012 Feb 8.

 

Nicotine Induces Negative Energy Balance Through Hypothalamic AMP-Activated Protein Kinase.

Martínez de Morentin PB, Whittle AJ, Fernø J, Nogueiras R, Diéguez C, Vidal-Puig A, López M. Diabetes. 2012 Feb 7.

 

PPARγ DEPENDENT REGULATION OF LIPOLYTIC NODES AND METABOLIC FLEXIBILITY.

Rodriguez-Cuenca S, Carobbio S, Velagapudi VR, Barbarroja N, Moreno-Navarrete JM, Tinahones FJ, Fernandez-Real JM, Oresic M, Vidal-Puig A. Moll Cell Biol. 2012 Feb 6.

 

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM(+/-)/ApoE(-/-) mice.

Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR. Free Radic Biol Med. 2012 Mar 1;52(5):841-9.

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Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat.

Jassim G, Skrede S, Vázquez MJ, Wergedal H, Vik-Mo AO, Lunder N, Diéguez C, Vidal-Puig A, Berge RK, López M, Steen VM, Fernø J. Psychopharmacology (Berl). 2012 Feb;219(3):783-94.

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2011

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Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass.

Vivas Y, Martinez-Garcia C, Izquierdo A, Garcia-Garcia F, Callejas S, Velasco I, Campbell M, Ros M, Dopazo A, Dopazo J, Vidal-Puig A, Medina-Gomez G. BMC Med Genomics. 2011 Dec 30;4(1):86.

 

Postprandial inflammatory response in adipose tissue of patients with metabolic syndrome after the intake of different dietary models.

Meneses ME, Camargo A, Perez-Martinez P, Delgado-Lista J, Cruz-Teno C, Jimenez-Gomez Y, Paniagua JA, Gutierrez-Mariscal FM, Tinahones FJ, Vidal-Puig A, Roche HM, Perez-Jimenez F, Malagon MM, Lopez-Miranda J.  Mol Nutr Food Res. 2011 Dec;55(12):1759-70.

 

Carbon-nanoparticle-triggered acute lung inflammation and its resolution are not altered in PPARgamma-defective (P465L) mice.

Gotz AA, Vidal-Puig A, Rodel HG, Hrabe de Angelis M, Stoeger T. . Part Fibre Toxicol. 2011 Sep 20;8:28.

 

Olanzapine, but not aripiprazole, weight-independently elevates serum triglycerides and activates lipogenic gene expression in female rats.

Skrede S, Fernø J, Vázquez MJ, Fjær S, Pavlin T, Lunder N, Vidal-Puig A, Diéguez C, Berge RK, López M, Steen VM. Int J Neuropsychopharmacol. 2011 Aug 19:1-17.

 

PGC-1{beta} Deficiency Accelerates the Transition to Heart Failure in Pressure Overload Hypertrophy.

Riehle C, Wende AR, Zaha VG, Pires KM, Wayment B, Olsen C, Bugger H, Buchanan J, Wang X, Moreira AB, Doenst T, Medina-Gomez G, Litwin SE, Lelliott CJ, Vidal-Puig A, Abel ED. Circ Res. 2011 Sep 16;109(7):783-93.

 

Genome-Wide Profiling of MicroRNAs in Adipose Mesenchymal Stem Cell Differentiation and Mouse Models of Obesity.

Bengestrate L, Virtue S, Campbell M, Vidal-Puig A, Hadaschik D, Hahn P, Bielke W. PLoS One. 2011;6(6):e21305.

 

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile.

Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS, Luan J, Vandenput L, Styrkarsdottir U, Zhou Y, Smith AV, Zhao JH, Amin N, Vedantam S, Shin SY, Haritunians T, Fu M, Feitosa MF, Kumari M, Halldorsson BV, Tikkanen E, Mangino M, Hayward C, Song C, Arnold AM, Aulchenko YS, Oostra BA, Campbell H, Cupples LA, Davis KE, Döring A, Eiriksdottir G, Estrada K, Fernández-Real JM, Garcia M, Gieger C, Glazer NL, Guiducci C, Hofman A, Humphries SE, Isomaa B, Jacobs LC, Jula A, Karasik D, Karlsson MK, Khaw KT, Kim LJ, Kivimäki M, Klopp N, Kühnel B, Kuusisto J, Liu Y, Ljunggren O, Lorentzon M, Luben RN, McKnight B, Mellström D, Mitchell BD, Mooser V, Moreno JM, Männistö S, O'Connell JR, Pascoe L, Peltonen L, Peral B, Perola M, Psaty BM, Salomaa V, Savage DB, Semple RK, Skaric-Juric T, Sigurdsson G, Song KS, Spector TD, Syvänen AC, Talmud PJ, Thorleifsson G, Thorsteinsdottir U, Uitterlinden AG, van Duijn CM, Vidal-Puig A, Wild SH, Wright AF, Clegg DJ, Schadt E, Wilson JF, Rudan I, Ripatti S, Borecki IB, Shuldiner AR, Ingelsson E, Jansson JO, Kaplan RC, Gudnason V, Harris TB, Groop L, Kiel DP, Rivadeneira F, Walker M, Barroso I, Vollenweider P, Waeber G, Chambers JC, Kooner JS, Soranzo N, Hirschhorn JN, Stefansson K, Wichmann HE, Ohlsson C, O'Rahilly S, Wareham NJ, Speliotes EK, Fox CS, Laakso M, Loos RJ. Nat Genet. 2011 Jun 26;43(8):753-60.

 

Olanzapine-Induced Hyperphagia and Weight Gain Associate with Orexigenic Hypothalamic Neuropeptide Signaling without Concomitant AMPK Phosphorylation.

Fernø J, Varela L, Skrede S, Vázquez MJ, Nogueiras R, Diéguez C, Vidal-Puig A, Steen VM, López M. PLoS One. 2011;6(6):e20571.

 

Association of lipidome remodelling in the adipocyte membrane with acquired obesity in humans.

Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M. PLoS Biol.  2011 Jun;9(6):e1000623.

 

Deletion of the metabolic transcriptional coactivator PGC1{beta} induces cardiac arrhythmia.

Gurung IS, Medina-Gomez G, Kis A, Baker M, Velagapudi V, Neogi SG, Campbell M, Rodriguez-Cuenca S, Lelliott C, McFarlane I, Oresic M, Grace AA, Vidal-Puig A*, Huang CL. Cardiovasc Res. 2011 Oct 1;92(1):29-38. (*Corresponding author)

 

Peroxisome proliferator-activated receptor-{gamma} coactivator 1-{alpha} (PGC1{alpha}) is a metabolic regulator of intestinal epithelial cell fate.

D'Errico I, Salvatore L, Murzilli S, Lo Sasso G, Latorre D, Martelli N, Egorova AV, Polishuck R, Madeyski-Bengtson K, Lelliott C, Vidal-Puig AJ, Seibel P, Villani G, Moschetta A. Proc Natl Acad Sci USA. 2011 Apr 19;108(16):6603-8.

 

Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice.

Prieur X, Mok CY, Velagapudi VR, Núñez V, Fuentes L, Montaner D, Ishikawa K, Camacho A, Barbarroja N, O'Rahilly S, Sethi J, Dopazo J, Oresic M, Ricote M, Vidal-Puig A. Diabetes. 2011 Mar;60(3):797-809.

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2010

 

Electrical and optical spectroscopy for quantitative screening of hepatic steatosis in donor livers.

McLaughlin BL, Wells AC, Virtue S, Vidal-Puig A, Wilkinson TD, Watson CJ, Robertson PA. Phys Med Biol. 2010 Nov 21;55(22):6867-79.

 

Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance.

Lopez M, Varela L, Vázquez MJ, Rodríguez-Cuenca S, González R, Velagapudi VR, Morgan DA, Schoenmakers E, Chatterjee K, Saha AK, Rahmouni K, Diéguez C, Vidal-Puig A. Nat Med. 2010 Sep;16(9):1001-8.

 

LEM-PCR: a method for determining relative transcript isoform proportions using real-time PCR without a standard curve.

Virtue S, Dale M, Sethi JK, Vidal-Puig A. Genome. 2010 Aug;53(8):637-42.

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DNA Damage Links Mitochondrial Dysfunction to Atherosclerosis and the Metabolic Syndrome.

Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M. Circ Res. 2010 Oct 15;107(8):1021-31.

 

The obese healthy paradox: is inflammation the answer?

Barbarroja N, Lopez-Pedrera R, Mayas MD, Garcia-Fuentes E, Garrido-Sanchez L, Macias-Gonzalez M, El Bekay R, Vidal-Puig A, Tinahones FJ. Biochem J. 2010 Aug 15;430(1):141-9.

 

Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.

Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešič M, Sethi JK, Vidal-Puig A. Int J Obes (Lond). 2010 Dec;34(12):1695-705.

 

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.

Szopa M, Meirhaeghe A, Luan J, Moreno LA, Gonzalez-Gross M, Vidal-Puig A, Cooper C, Hagen R, Amouyel P, Wareham NJ, Loos RJ. Am J Clin Nutr July 2010;92 (1):252-7.

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Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender.

Lage R, Vázquez MJ, Varela L, Saha AK, Vidal-Puig A, Nogueiras R, Diéguez C, López M. FASEB J. 2010 Aug;24(8):2670-9.

 

Extracellular Fatty Acid Synthase: a possible surrogate biomarker of insulin resistance

Fernandez-Real JM, Menendez JA, Moreno-Navarrete JM, Blüher M, Vazquez-Martin A, Vázquez MJ, Ortega F, Diéguez C, Frühbeck G, Ricart W, Vidal-Puig A. . Diabetes. 2010 Jun;59(6):1506-11.

 

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

Rodriguez-Cuenca S, Cochemé HM, Logan A, Abakumova I, Prime TA, Rose C, Vidal-Puig A, Smith AC, Rubinsztein DC, Fearnley IM, Jones BA, Pope S, Heales SJ, Lam BY, Neogi SG, McFarlane I, James AM, Smith RA, Murphy MP.Free Radic Biol Med. 2010 Jan 1;48(1):161-72.​​