Dr. Michele Vacca

Email: mv400@medschl.cam.ac.uk


About Michele

Michele is a Senior Clinician Scientist at the Medical Research Council – Human Nutrition Research (MRC-HNR) and research fellow in the TVP Lab. After his medical studies at the University of Bari (Italy, 2002), Michele specialised in Internal Medicine (2008) and completed his PhD in Oncology and Molecular and Clinical Pathology at the University of Chieti-Pescara (Italy) in 2012 (Topic: Nor-1 is a primary hepatic mitogen). From 2008 to 2014 Michele was also research fellow of the Consorzio Mario Negri Sud (Italy), and visiting clinician at the Ambulatory of Clinical Nutrition, Clinica Medica Murri, University of Bari.

Research Interests

Michele’s main clinical interest lies in the area of obesity, particularly the interaction between nutrition, obesity and the development of cardio-metabolic disease. His main scientific interest is the role of Nuclear Receptors and miRNAs in the modulation of metabolism, metabolic disease, cell proliferation and cancer.


Vacca M, Murzilli S, Salvatore L, Di Tullio G, D’Orazio A, Lo Sasso G, Graziano G, Pinzani M, Chieppa M, Mariani-Costantini R, Palasciano G, Moschetta A. Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes. Gastroenterology 2013;144:1518-1529. (IF2012: 12.821) – PMID: 23462179

Vacca M, Degirolamo C, Massafra V, Polimeno L, Mariani-Costantini R, Palasciano G, Moschetta A. Nuclear receptors in regenerating liver and hepatocellular carcinoma. Mol Cell Endocrinol 2013;368:108-119. (IF2012: 4.039) – PMID: 22789748

D’Amore S, Vacca M, Graziano G, D’Orazio A, Cariello M, Martelli N, Di Tullio G, Salvia R, Grandaliano G, Belfiore A, Pellegrini F, Palasciano G, Moschetta A. Nuclear receptors expression chart in peripheral blood mononuclear cells identifies patients with Metabolic Syndrome. Biochim Biophys Acta. 2013 Dec;1832 (12):2289-301. (IF2012: 4.910) – PMID: 24060638

Cama A, Verginelli F, Lotti LV, Napolitano F, Morgano A, D’Orazio A, Vacca M, Perconti S, Pepe F, Romani F, Vitullo F, di Lella F, Visone R, Mannelli M, Neumann HPH, Raiconi G, Paties C, Moschetta A, Tagliaferri R, Veronese A, Sanna M, Mariani-Costantini R. Integrative Genetic, Epigenetic And Pathological Analysis Of Paraganglioma Reveals Complex Dysregulation Of Notch Signaling. Acta Neuropathologica 2013; 126(4): 575-94. (IF2012: 9.734) – PMID: 23955600

Lo Sasso G, Bovenga F, Murzilli S, Salvatore L, Di TG, Martelli N, D’Orazio A, Rainaldi S, Vacca M, Mangia A, Palasciano G, Moschetta A. Liver x receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice. Gastroenterology 2013;144:1497-1507. (IF2012: 12.821) – PMID: 23419360

Lo Sasso G, Celli N, Caboni M, Murzilli S, Salvatore L, Morgano A, Vacca M, Pagliani T, Parini P, Moschetta A. Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes. Hepatology 2010;51:1334-1344. (IF2010: 11.044) – PMID: 20044803

Vacca M, Degirolamo C, Mariani-Costantini R, Palasciano G, Moschetta A. Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. Wiley Interdiscip Rev Syst Biol Med 2011;3:562-587. (IF2011: 2.941) – PMID: 21755605

Vacca M, Krawczyk M, Petruzzelli M, Sasso RC, Van Erpecum KJ, Palasciano G, van Berge-Henegouwen GP, Moschetta A, Portincasa P. Current treatments of primary sclerosing cholangitis. Curr Med Chem 2007;14:2081-2094. (IF2007: 4.944) – PMID: 17691949

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