Jennie Leggat

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Email:

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About me

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• 2011-2014: MA Natural Sciences, University of Cambridge

• 2014-2017: Clinical Cardiac Scientist, Royal Berkshire Hospital

• 2014-2017: MSc Clinical Sciences, Newcastle University

• 2017-2018: MRes Medical Sciences, University of Cambridge

• 2018-present: BHF PhD Cardiovascular Research, TVPLab, Institute of Metabolic Science, University of Cambridge 

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Research Interests

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I am interested in how non-alcoholic fatty liver disease (NAFLD) affects the pathogenesis and progression of heart failure with preserved ejection fraction (HFpEF). I am using both in vitro and in vivo models to investigate liver-heart crosstalk in NAFLD in order to identify mechanistic links mediating the clinically-observed coexistence of NAFLD and HFpEF, with the ultimate aim of elucidating potential therapeutic strategies to prevent HFpEF in this context.

Publications​

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Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M, Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, Binder CJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi: 10.1161/ATVBAHA.118.312272. Epub 2019 May 16.

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