2011-2014: MA Natural Sciences, University of Cambridge
2014-2017: Clinical Cardiac Scientist, Royal Berkshire Hospital
2014-2017: MSc Clinical Sciences, Newcastle University
2017-2018: MRes Medical Sciences, University of Cambridge
2018-present: BHF PhD Cardiovascular Research, TVPLab, Institute of Metabolic Science, University of Cambridge
I am interested in how non-alcoholic fatty liver disease (NAFLD) affects the pathogenesis and progression of heart failure with preserved ejection fraction (HFpEF). I am using both in vitro and in vivo models to investigate liver-heart crosstalk in NAFLD in order to identify mechanistic links mediating the clinically-observed coexistence of NAFLD and HFpEF, with the ultimate aim of elucidating potential therapeutic strategies to prevent HFpEF in this context.
Fletcher-Etherington, A., Mackinlay, K., Leggat, J., Baird, T., Simpson-Kent, I. L., & Rendina, C. The effect of Council decision making on the ability of Cambridgeshire communities to develop initiatives that lessen the need for formal health and social care services. SocArXiv 2021. https://doi.org/10.31235/osf.io/jh2gm
Leggat, J. 'Processing' nutrition advice: how to inform guidelines on ultra-processed food. Cambridge Journal of Science and Policy 2020;1(2):e8214808651. https://doi.org/10.17863/CAM.53167
Bagchi-Chakraborty J, Francis A, Bray T, Masters L, Tsiantoulas D, Nus M, Harrison J, Broekhuizen M, Leggat J, Clatworthy MR, Espéli M, Smith KGC, Binder CJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi: 10.1161/ATVBAHA.118.312272.