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Jennie Leggat


About me

  • 2011-2014: MA Natural Sciences, University of Cambridge

  • 2014-2017: Clinical Cardiac Scientist, Royal Berkshire Hospital

  • 2014-2017: MSc Clinical Sciences, Newcastle University

  • 2017-2018: MRes Medical Sciences, University of Cambridge

  • 2018-present: BHF PhD Cardiovascular Research, TVPLab, Institute of Metabolic Science, University of Cambridge 

Research Interests

I am interested in how non-alcoholic fatty liver disease (NAFLD) affects the pathogenesis and progression of heart failure with preserved ejection fraction (HFpEF). I am using both in vitro and in vivo models to investigate liver-heart crosstalk in NAFLD in order to identify mechanistic links mediating the clinically-observed coexistence of NAFLD and HFpEF, with the ultimate aim of elucidating potential therapeutic strategies to prevent HFpEF in this context.

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Fletcher-Etherington, A., Mackinlay, K., Leggat, J., Baird, T., Simpson-Kent, I. L., & Rendina, C. The effect of Council decision making on the ability of Cambridgeshire communities to develop initiatives that lessen the need for formal health and social care services. SocArXiv 2021.

Leggat, J. 'Processing' nutrition advice: how to inform guidelines on ultra-processed food. Cambridge Journal of Science and Policy 2020;1(2):e8214808651.

Bagchi-Chakraborty J, Francis ABray TMasters LTsiantoulas DNus MHarrison JBroekhuizen MLeggat JClatworthy MREspéli MSmith KGCBinder CJ, Mallat Z, Sage AP. B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses. Arterioscler Thromb Vasc Biol. 2019 Jul;39(7):1379-1389. doi: 10.1161/ATVBAHA.118.312272.

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