Dr Eunyoung Lee

研究方向

我的研究主要通过小鼠实验，阐明身体如何协调多组织之间的相互作用，例如脑—肝—胰腺—脂肪组织—肌肉—肠道轴，以维持葡萄糖与能量稳态，以及这些过程如何在肥胖和糖尿病等病理生理状态下失调。组织间的交流可能由脂肪酸、脂质、组织分泌的激素等代谢物介导，也可能通过交感神经系统进行。我的目标是寻找这些代谢物，阐明其生理学意义，并进一步通过体外实验在细胞层面探索相关分子机制。

背景与经历

我是一名来自日本的访问研究人员，于 2018 年加入 TVP Lab。我关注在生理条件下葡萄糖与能量稳态如何受到调控。

代表性论文与成果

1. Lee, E.Y., L. Miedzybrodzka, E., Zhang, X., Hatano, R., Miyamoto, J., Kimura, I., Fujimoto, K., Uematsu, S., Rodriguez-Cuenca, S., Vidal-Puig, A., M.Gribble, F., Reimann, F., Miki, T. (2019) Diet-induced obese mice and leptin-deficient Lepob/ob mice exhibit increased circulating GIP levels produced by different mechanisms.Int.J.Mol.Sci. 4448.
2. Lee, E.Y., Zhang, X., Miyamoto, J., Kimura, I., Tanaka, T., Furusawa, K., Jomori, T., Fujimoto, K., Uematsu, S., Miki, T. (2018) Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway. J Endocrinol 239:267-76.
3. Kitamoto, T., Sakurai, K., Lee, E.Y.,Yokote, K., Accili, D., Miki, T. (2018) Distinct roles of systemic and local actions of insulin on pancreatic β-cells. Metabolism 81:100-10.
4. Miki, T., Lee, E.Y., Eguchi, A., Sakurai, K., Sawabe, Y., Yoshida, T., Saito, K., Yokoh, H., Ishikawa, K., Yokote, K., Kuzuya, T., Miki, E., Mori, C., Nomura, F. (2017) Accelerated oligosaccharide absorption and altered serum metabolites during oral glucose tolerance test in young Japanese with impaired glucose tolerance. J Diabetes Investig 9: 512-521.
5. Morimoto, M.*, Lee, E.Y.* (* co-first authors), Zhang, X., Inaba, Y., Inoue, H., Ogawa, M., Shirasawa, T., Yokosuka, O., Miki, T. (2016) Eicosapentaenoic acid ameliorates hyperglycemia in high-fat diet-sensitive diabetes mice in conjunction with restoration of hypoadiponectinemia. Nutr Diabetes 6, e213.
6. Morita, A., Mukai, E., Hiratsuka, A., Takatani, T., Iwanaga, T., Lee, EY., Miki T. (2016) Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function. Endocrine 51:429-39.
7. Hirono, S.*, Lee, E.Y.* (* co-first authors), Kuribayashi, S., Fukuda, T., Saeki, N., Minokoshi, Y., Iwanaga, T., Miki, T. (2016) Importance of adult Dmbx1 in long-lasting orexigenic effect of agouti-related peptide. Endocrinology 157:245-57.
8. Lee, E.Y., Sakurai, K., Zhang, X., Toda, C., Tanaka, T., Jiang, M., Shirasawa, T., Tachibana, K., Yokote, K., Vidal-Puig, A., Minokoshi, Y., Miki, T. (2015) Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in InsrP1195L/+ mice fed high-fat-diet. Scientific Reports 5:17565.
9. Lee, E.Y., Kaneko, S., Jutabha, P., Zhang, X., Seino, S., Jomori, T., Anzai, N., Miki, T. (2015) Distinct action of the α-glucosidase inhibitor miglitol on SGLT3, enteroendocrine cells, and GLP1 secretion. J Endocrinol 224:205-14
10. Mukaia, E., Ohta T., Kawamura H., Lee, E.Y., Morita A., Sasase T., Miyajima K., Inagaki N., Iwanaga T., Miki T. (2014) Enhanced vascular endothelial growth factor signaling in islets contributes to β cell injury and consequential diabetes in spontaneously diabetic Torii rats. Diabetes Research and Clinical Practice 106:303-11.
11. Seino Y, Miki M, Fujimoto W, Lee, E.Y.,Takahashi Y, Minami K, Oiso Y, Seino S (2013) Cephalic phase insulin secretion is KATP channel-independent. J Endocrinol 218:25-33.