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Postdoctoral Researcher
Dr. Vanessa Pellegrinelli
Email: vp332@medschl.cam.ac.uk
About me
I am a Research Associate working on different aspects of adipose tissue structural networks including extracellular matrix remodelling. An integrative physiologist with considerable experience in adipose tissue biology and animal phenotyping. Responsible, hardworking and highly organized with a problem-solving attitude. Easily adaptable to multicultural environments, holding a strong commitment to scientific collaboration.
Research Interests
By combining in vivo and in vitro models mimicking pathophysiological conditions with imaging and systems biology approaches, I am investigating how impaired adipose tissue plasticity may influence tissue functionality.
Publications
Pellegrinelli, V., Figueroa-Juarez, E., Samuelson, I., U-Din, M., Rodriguez-Fdez, S., Virtue, S., Leggat, J., Cubuk, C., Peirce, V.J., Niemi, T. and Campbell, M., 2023. Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis. Cell Reports, 42(6).
Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Figueroa-Juarez, E., Schilbert, H., Virtue, S., Moreno-Navarrete, J.M., Bidault, G., Vázquez-Borrego, M.C., Dias, A.R. and Pucker, B., 2022. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nature metabolism, 4(4), pp.476-494.
Pellegrinelli V, Peirce VJ, Howard L, Virtue S, Türei D, Senzacqua M, Frontini A, Dalley JW, Horton AR, Bidault G, Severi I, Whittle A, Rahmouni K, Saez-Rodriguez J, Cinti S, Davies AM, Vidal-Puig A. Nat Commun, 2018.
Pellegrinelli V, Rouault C, Rodriguez-Cuenca S, Albert V, Edom-Vovard F, Vidal-Puig A, Clément K, Butler-Browne G, Lacasa D. Human adipocytes induce inflammation and atrophy in muscle cells during obesity. Diabetes, 2015.
Pellegrinelli V, Heuvingh J, du Roure O, Rouault C, Devulder A, Klein C, Lacasa M, Clément E, Lacasa D, Clément K. Human adipocyte function is impacted by mechanical cues.J Pathol, 2014.
Pellegrinelli V, Rouault C, Veyrie N, Clément K and Lacasa D.Endothelial Cells From Visceral Adipose Tissue Disrupt Adipocyte Functions In A 3D Setting: Partial Rescue By Angiopoietin-1. Diabetes, 2014.
Lacasa D, Pellegrinelli V, Keophiphath M, Clement K. International patent UPMC N°PCT/IB2011/O52241, WO2011148310-A1; FR2960549-A1; AU2011259756-A1; CA2800667-A1; EP2576770-A1; CN102985533-A; JP2013526291-W; US2013183706-A1.« Culture procedure of human mature adipocytes »