Key Publications

Reviews & Editorial

Our Research

Our program of research explores the molecular mechanisms involved in controlling energy expenditure, fat deposition, and the mechanisms controlling the partition of energy towards oxidation or storage. Below is a selection of publications from the lab on this topic.

Publications

2025

Distinct signalling dynamics of BMP4 and BMP9 in brown versus white adipocytes.

Constant B, Kamzolas I, Yang X, Guo J, Rodriguez-Fdez S, Mali I, Rodriguez-Cuenca S, Petsalaki E, Vidal-Puig A, Li W.

Sci Rep. 8;15(1):15971. doi: 10.1038/s41598-025-99122-5. PMID: 40335635. PMCID: PMC12059129

Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise.

Vujic A, Koo A, Bidault G, Miljkovic JL, James AM, Dannhorn A, Duan X, Davis LM, Abe J, Valadares J, Lee JJ, Diaz-Vegas A, Turner K, Goodwin R, Fazakerley DJ, Vidal Puig A, Murphy MP, Krieg T.

Am J Physiol Heart Circ Physiol.

Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease.

Mocciaro G, George AL, Allison M, Frontini M, Huang-Doran I, Reiman F, Gribble F, Griffin JL, Vidal-Puig A, Azzu V, Kay R, Vacca M.

Liver Int.

Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice.

Luk C, Bridge KI, Warmke N, Simmons KJ, Drozd M, Moran A, MacCannell ADV, Cheng CW, Straw S, Scragg JL, Smith J, Ozber CH, Wilkinson CG, Skromna A, Makava N, Prag HA, Simon Futers T, Brown OI, Bruns AF, Walker AM, Watt NT, Mughal R, Griffin KJ, Yuldasheva NY, Limumpornpetch S, Viswambharan H, Sukumar P, Beech DJ, Vidal-Puig A, Witte KK, Murphy MP, Hartley RC, Wheatcroft SB, Cubbon RM, Roberts LD, Kearney MT, Haywood NJ.

Nat Commun.

2024

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD).

Vacca, M., Kamzolas, I., Harder, L. M., Oakley, F., Trautwein, C., Hatting, M., ... & Vidal-Puig, A.

Nature Metabolism. 2024

https://www.nature.com/articles/s42255-024-01038-x

Systemic analysis of lipid metabolism from individuals to multi-organism systems.

Furse S, Martel C, Willer DF, Stabler D, Fernandez-Twinn DS, Scott J, Patterson-Cross R, Watkins AJ, Virtue S, Prescott TAK, Baker E, Chennells J, Vidal-Puig A, Ozanne SE, Kite GC, Vítová M, Chiarugi D, Moncur J, Koulman A, Wright GA, Snowden SG, Stevenson PC.

Mol Omics.

https://doi.org/10.1039/D4MO00129F

The role of brown adipose tissue in branched-chain amino acid clearance in people.

Abdelhafez YG, Wang G, Li S, Pellegrinelli V, Chaudhari AJ, Ramirez A, Sen F, Vidal-Puig A, Sidossis LS, Klein S, Badawi RD, Chondronikola M.

iScience. 2024 Jul

https://doi.org/10.1016/j.isci.2024.110678

Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase.

Hu YT, Liu ZW, Zhang TH, Ma YE, He L, Zhang J, Zhou YY, Vidal-Puig A, Pan DJ, Wu F.

Acta Pharmacol Sin.

https://doi.org/10.1038/s41401-024-01376-8

SMIM1 absence is associated with reduced energy expenditure and excess weight.

Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S; DBDS Genetic Consortium; Chen J; MAGIC; Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M.

Med. 2024 Jun

https://doi.org/10.1016/j.medj.2024.04.013

The strategy behind one of the most successful labs in the world (2024).

Gebel L, Velu C, Vidal-Puig A.

Nature 2024 Jun;630(8018):813-816. doi: 10.1038/d41586-024-02085-2. PMID: 38926627

https://www.nature.com/articles/d41586-024-02085-2

Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring, leading to altered fatty acid sensing and increased intake of high-fat food.

Dearden L, Furigo IC, Pantaleão LC, Wong LWP, Fernandez-Twinn DS, de Almeida-Faria J, Kentistou KA, Carreira MV, Bidault G, Vidal-Puig A, Ong KK, Perry JRB, Donato J Jr, Ozanne SE.

PLoS Biol. 2024 Jun 4;22(6):e3002641. doi: 10.1371/journal.pbio.3002641. eCollection 2024 Jun. PMID: 38833481

https://doi.org/10.1371/journal.pbio.3002641

Tissue-specific inflammation and insulin sensitivity in subjects with obesity.

Oussaada SM, Kilicarslan M, de Weijer BA, Gilijamse PW, Şekercan A, Virtue S, Janssen IMC, van de Laar A, Demirkiran A, van Wagensveld BA, Houdijk APJ, Jongejan A, Moerland PD, Verheij J, Geijtenbeek TB, Bloks VW, de Goffau MC, Romijn JA, Nieuwdorp M, Vidal-Puig A, Ter Horst KW, Serlie MJ.

Diabetes Res Clin Pract. 2024 May;211:111663. doi: 10.1016/j.diabres.2024.111663. Epub 2024 Apr 12. PMID: 38616042

https://doi.org/10.1016/j.diabres.2024.111663

Limited oxygen in standard cell culture alters metabolism and function of differentiated cells.

Tan J, Virtue S, Norris DM, Conway OJ, Yang M, Bidault G, Gribben C, Lugtu F, Kamzolas I, Krycer JR, Mills RJ, Liang L, Pereira C, Dale M, Shun-Shion AS, Baird HJ, Horscroft JA, Sowton AP, Ma M, Carobbio S, Petsalaki E, Murray AJ, Gershlick DC, Nathan JA, Hudson JE, Vallier L, Fisher-Wellman KH, Frezza C, Vidal-Puig A*, Fazakerley DJ.

EMBO J. 2024 Apr 5. doi: 10.1038/s44318-024-00084-7. PMID: 38580776

https://doi.org/10.1038/s44318-024-00084-7

Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation.

Ng MY, Song ZJ, Venkatesan G, Rodriguez-Cuenca S, West JA, Yang S, Tan CH, Ho PC, Griffin JL, Vidal-Puig A, Bassetto M, Hagen T.

Sci Rep. 2024 Feb 28;14(1):4932. doi: 10.1038/s41598-024-54466-2. PMID: 38418847

https://www.nature.com/articles/s41598-024-54466-2

Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline.

Yu Y, Yang J, Zheng L, Su H, Cao S, Jiang X, Liu X, Liu W, Wang Z, Meng F, Xu H, Wen D, Sun C, Song X, Vidal-Puig A, Cao L.

Mol Metab. 2024 Mar;81:101892. doi: 10.1016/j.molmet.2024.101892. PMID: 38331318

https://doi.org/10.1016/j.molmet.2024.101892

2023

Defective extracellular matrix remodeling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis.

Pellegrinelli, V., Figueroa-Juarez, E., Samuelson, I., Mueez, U. D., Rodriguez-Fdez, S., Virtue, S., ... & Vidal-Puig, A. (2023)

Cell Reports. 2023

https://doi.org/10.1016/j.celrep.2023.113456

Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice.

Xu J, Cui L, Wang J, Zheng S, Zhang H, Ke S, Cao X, Shi Y, Li J, Zen K, Vidal-Puig A*, Zhang CY, Li L, Jiang X.

Nat Commun. 2023 Sep 6;14(1):5480. doi: 10.1038/s41467-023-41160-6. PMID: 37673898

https://www.nature.com/articles/s41467-023-41160-6

Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study.

Soria-Gondek A, Fernández-García P, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Pellitero S, Tarascó J, Jenkins B, Galán M, Villarroya F, Koulman A, Corrales P, Vidal-Puig A, Cereijo R, Sánchez-Infantes D.

Nutrients. 2023 Jul 27;15(15):3341. doi: 10.3390/nu15153341. PMID: 37571279

https://doi.org/10.3390/nu15153341

Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis.

Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint-Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators.

Lancet Gastroenterol Hepatol. 2023 Jun 5:S2468-1253(23)00141-3. doi: 10.1016/S2468-1253(23)00141-3. PMID: 37290471

https://doi.org/10.1016/S2468-1253(23)00141-3

Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning.

Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R.

iScience. 2023 May 9;26(6):106847. doi: 10.1016/j.isci.2023.106847. PMID: 37250773

https://doi.org/10.1016/j.isci.2023.106847

Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis.

Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C.

Mol Metab. 2023 Apr 28;73:101731. doi: 10.1016/j.molmet.2023.101731. PMID: 37121509

https://doi.org/10.1016/j.molmet.2023.101731

Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL).

Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M.

Mol Metab. 2023 Apr 19;73:101728. doi: 10.1016/j.molmet.2023.101728. PMID: 37084865

https://doi.org/10.1016/j.molmet.2023.101728

Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study.

Lee J, Westphal M, Vali Y, Boursier J, Ostroff R, Alexander L, Chen Y, Fournier C, Geier A, Francque S, Wonders K, Tiniakos D, Bedossa P, Allison M, Papatheodoridis G, Cortez-Pinto H, Pais R, Dufour JF, Leeming DJ, Harrison S, Cobbold J, Holleboom AG, Yki-Järvinen H, Crespo J, Ekstedt M, Aithal GP, Bugianesi E, Romero-Gomez M, Karsdal M, Yunis C, Schattenberg JM, Schuppan D, Ratziu V, Brass C, Duffin K, Zwinderman K, Pavlides M, Anstee QM, Bossuyt PM; LITMUS investigators.

Hepatology. 2023 Mar 31. doi: 10.1097/HEP.0000000000000364. PMID: 36994719

https://doi.org/10.1097/HEP.0000000000000364

Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons.

Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A.

Mol Cell. 2023 Mar 3:S1097-2765(23)00114-4. doi: 10.1016/j.molcel.2023.02.011. PMID: 36917981

https://doi.org/10.1016/j.molcel.2023.02.011

CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells.

Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S.

Int J Mol Sci. 2023 Feb 8;24(4):3399. doi: 10.3390/ijms24043399. PMID: 36834818

https://doi.org/10.3390/ijms24043399

2022

Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway.

Zhai, Q., Zeng, Y., Gu, Y., Li, Z., Zhang, T., Yuan, B., ... & Xu, Y. (2022).

iScience, 25(5)

https://doi.org/10.1016/j.isci.2022.104267

Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease.

Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešič M.

iScience. 2022 Aug 15;25(9):104949. doi: 10.1016/j.isci.2022.104949. PMID: 36065182

https://doi.org/10.1016/j.isci.2022.104949

Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis.

Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A.

Autophagy.2022 Aug 25:1-22. doi: 10.1080/15548627.2022.2111081. PMID: 35947488

https://doi.org/10.1080/15548627.2022.2111081

Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest.

Li C, Feng Y, Fu Z, Deng J, Gu Y, Wang H, Wu X, Huang Z, Zhu Y, Liu Z, Huang M, Wang T, Hu S, Yao B, Zeng Y, Zhou CJ, Brown SDM, Liu Y, Vidal-Puig A, Dong Y, Xu Y.

Cell Death Discov. 2022 Aug 2;8(1):345. doi: 10.1038/s41420-022-01139-6. PMID: 35918318. PMCID: PMC9345867

https://doi.org/10.1038/s41420-022-01139-6

TRIM24 is an insulin-responsive regulator of P-bodies.

Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S.

Nat Commun. 2022 Jul 8;13(1):3972. doi: 10.1038/s41467-022-31735-0. PMID: 35803934

https://www.nature.com/articles/s41467-022-31735-0

Time-restricted feeding entrains long-term behavioural changes through the IGF2-KCC2 pathway.

Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y.

iScience. 2022 Apr 18;25(5):104267. doi: 10.1016/j.isci.2022.104267. PMID: 35521538. PMCID: PMC9062755

https://doi.org/10.1016/j.isci.2022.104267

Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance.

Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C., Vidal-Puig A.

Nat Metab 4, 476–494 (2022). doi: 10.1038/s42255-022-00561-5. PMID: 35478031

https://doi.org/10.1038/s42255-022-00561-5

Dietary PUFA drives various systems-level changes in lipid metabolism.

Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A.

Mol Metab. 2022 Feb 9;101457. doi: 10.1016/j.molmet.2022.101457. PMID: 35150907

https://doi.org/10.1016/j.molmet.2022.101457

2021

Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance.
Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators§; LITMUS Consortium Investigators.JHEP Rep. 2021 Nov 25;4(2):100409. doi: 10.1016/j.jhepr.2021.100409. eCollection 2022 Feb.PMID: 35072021 Free PMC article.

β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development.
Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L.Sci Transl Med. 2021 Dec 15;13(624):eabk2267. doi: 10.1126/scitranslmed.abk2267. Epub 2021 Dec 15.PMID: 34910547

What is the most appropriate covariate in ANCOVA when analysing metabolic rate?
Virtue S, Lelliott CJ, Vidal-Puig A.Nat Metab. 2021 Dec 13. doi: 10.1038/s42255-021-00505-5. Online ahead of print.PMID: 34903886

Insulin and the last gasp of failing adipocytes.
Rodriguez-Cuenca S, Vidal-Puig A.Nat Metab. 2021 Nov;3(11):1443-1444. doi: 10.1038/s42255-021-00492-7.PMID: 34732886

Lipotoxicity: a driver of heart failure with preserved ejection fraction?
Leggat J, Bidault G, Vidal-Puig A.Clin Sci (Lond). 2021 Oct 15;135(19):2265-2283. doi: 10.1042/CS20210127.PMID: 34643676

SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defences to promote their alternative activation
Guillaume Bidault 1, Samuel Virtue 2, Kasparas Petkevicius 2, Helen E Jolin 3, Aurélien Dugourd 4 5, Anne-Claire Guénantin 2 6, Jennifer Leggat 2, Betania Mahler-Araujo 2, Brian Y H Lam 2, Marcella K Ma 2, Martin Dale 2, Stefania Carobbio 2 6, Arthur Kaser 7, Padraic G Fallon 8, Julio Saez-Rodriguez 4, Andrew N J McKenzie 3, Antonio Vidal-Puig

Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans.
Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA.Front Endocrinol (Lausanne). 2021 Jul 26;12:739065. doi: 10.3389/fendo.2021.739065. eCollection 2021.PMID: 34381425 Free PMC article. No abstract available.

Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects.
Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Orešič M, Bjursell M, Bohlooly-Y M, Lindén D, Vidal-Puig A.FASEB J. 2021 Sep;35(9):e21752. doi: 10.1096/fj.202100262RR.PMID: 34369602

A pipeline for making 31P NMR accessible for small- and large-scale lipidomics studies.
Furse S, Williams HEL, Watkins AJ, Virtue S, Vidal-Puig A, Amarsi R, Charalambous M, Koulman A.Anal Bioanal Chem. 2021 Aug;413(19):4763-4773. doi: 10.1007/s00216-021-03430-4. Epub 2021 Jul 12.PMID: 34254158

GTTs and ITTs in mice: simple tests, complex answers.
Virtue S, Vidal-Puig A.Nat Metab. 2021 Jun 11. doi: 10.1038/s42255-021-00414-7. Online ahead of print.PMID: 34117483

Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3.
Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y.Cell Death Differ. 2021 Jun 5. doi: 10.1038/s41418-021-00798-9. Online ahead of print.PMID: 34091599

Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function
Mol Metab. 2021 Mar 24:101220. doi: 10.1016/j.molmet.2021.101220. Online ahead of print.PMID: 33774223 Free article.
Kasparas Petkevicius 1, Guillaume Bidault 2, Sam Virtue 2, Stephen A Newland 3, Martin Dale 2, Aurelien Dugourd 4, Julio Saez-Rodriguez 4, Ziad Mallat 3, Antonio Vidal-Puig 5

Suppression of insulin-induced gene 1(INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression.
Mol Metab. 2021 Mar 12:101210. doi: 10.1016/j.molmet.2021.101210. Online ahead of print.PMID: 33722690 Free article.
Vian Azzu 1, Michele Vacca 2, Ioannis Kamzolas 3, Zoe Hall 4, Jack Leslie 5, Stefania Carobbio 6, Sam Virtue 6, Susan E Davies 7, Agnes Lukasik 6, Martin Dale 6, Mohammad Bohlooly-Y 8, Animesh Acharjee 9, Daniel Lindén 10, Guillaume Bidault 6, Evangelia Petsalaki 11, Julian L Griffin 4, Fiona Oakley 5, Michael Ed Allison 12, Antonio Vidal-Puig 13

Unraveling the developmental roadmap toward human brown adipose tissue
Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A.Stem Cell Reports. 2021 Apr 13;16(4):1010. doi: 10.1016/j.stemcr.2021.03.009.PMID: 33852883 Free PMC article.

Obesity and pregnancy, the perfect metabolic storm.
Corrales P, Vidal-Puig A, Medina-Gómez G.Eur J Clin Nutr. 2021 Apr 28. doi: 10.1038/s41430-021-00914-5. Online ahead of print.PMID: 33911209

Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women.
Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR.Diabetes. 2021 Apr 15:db210011. doi: 10.2337/db21-0011. Online ahead of print.PMID: 33858825

Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand.
Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M.Sci Rep. 2021 Apr 8;11(1):7717. doi: 10.1038/s41598-021-87292-x.PMID: 33833312 Free PMC article.

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL.Hepatology. 2021 Mar;73(3):1028-1044. doi: 10.1002/hep.31391. Epub 2020 Nov 3.PMID: 32460431

Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis.
Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD.Nat Commun. 2021 Mar 26;12(1):1905. doi: 10.1038/s41467-021-22272-3.PMID: 33772024 Free article.

Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF.Nat Metab. 2021 Feb;3(2):228-243. doi: 10.1038/s42255-021-00346-2. Epub 2021 Feb 22.PMID: 33619380

Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family.
Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY.J Extracell Vesicles. 2021 Jan;10(3):e12055. doi: 10.1002/jev2.12055. Epub 2021 Jan 21.PMID: 33520119

Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation.
Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A.FASEB J. 2021 Feb;35(2):e21266. doi: 10.1096/fj.202001101R.PMID: 33484195

2020-2018

2020

GDF15 mediates the effects of metformin on body weight and energy balance.

Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S.

Nature. 2020 Feb;578(7795):444-448. doi: 10.1038/s41586-019-1911-y. Epub 2019 Dec 25.PMID: 31875646

Lipid Remodeling in Hepatocyte Proliferation and Hepatocellular Carcinoma.

Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL.

Hepatology. 2020 May 27. doi: 10.1002/hep.31391. Online ahead of print.PMID: 32460431

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis.

Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C.

Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006. Epub 2019 Oct 31.PMID: 31918923

Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis.

Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM.

Sci Transl Med. 2020 Dec 2;12(572):eaba4448. doi: 10.1126/scitranslmed.aba4448.PMID: 33268509

Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease.

Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A.Gastroenterology. 2020 May;

158(7):1899-1912. doi: 10.1053/j.gastro.2019.12.054. Epub 2020 Feb 13.PMID: 32061598

Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance.

Nature. 2020 Feb;578(7796):E24. doi: 10.1038/s41586-020-2031-4.PMID: 32051582

Bone morphogenetic protein 8B promotes the progression of non-alcoholic steatohepatitis.

Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A.

Nat Metab. 2020 Jun;2(6):514-531. doi: 10.1038/s42255-020-0214-9. Epub 2020 Jun 8.PMID: 32694734

Angiotensin-(1-7) induces beige fat thermogenesis through the Mas receptor.

Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I, Schcolnik-Cabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R, Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR.

Metabolism. 2020 Feb;103:154048. doi: 10.1016/j.metabol.2019.154048. Epub 2019 Dec 13.PMID: 31843339

Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation.

Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA.

BMJ Open Diabetes Res Care. 2020 Jan;8(1):e000945. doi: 10.1136/bmjdrc-2019-000945.PMID: 32049633

Studying Brown Adipose Tissue in a Human in vitro Context.

Samuelson I, Vidal-Puig A.Front Endocrinol (Lausanne). 2020 Sep 15;11:629.

doi: 10.3389/fendo.2020.00629. eCollection 2020.PMID: 33042008

Reply to: 'Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells'.

Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Shabeer M, Shyong Tai E, Vidal-Puig A, Toh SA.

Sci Rep. 2020 Jun 15;10(1):9634. doi: 10.1038/s41598-020-64706-w.PMID: 32541770

Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function.

Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M.

PLoS Genet. 2020 Oct 15;16(10):e1009069. doi: 10.1371/journal.pgen.1009069. eCollection 2020 Oct.PMID: 33057429 Free PMC article.

The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production.

Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR.

Sci Adv. 2020 Nov 25;6(48):eabd3139. doi: 10.1126/sciadv.abd3139. Print 2020 Nov.PMID: 33239297 Free PMC article.

Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure.

Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O'Rahilly S, Semple RK.

Mol Metab. 2020 Oct;40:101020. doi: 10.1016/j.molmet.2020.101020. Epub 2020 May 19.PMID: 32439336 Free PMC article.

Publisher Correction: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue.

Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC.

Nat Commun. 2020 Feb 21;11(1):1078. doi: 10.1038/s41467-020-14939-0.PMID: 32081871 Free PMC articl

Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease. Gastroenterology

Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A.. 2020 Feb 12. pii: S0016-5085(20)30224-9. doi:10.1053/j.gastro.2019.12.054. [Epub ahead of print] PubMed PMID: 32061598

2019

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis. .

Mol Metab. 2020 Jan;31:67-84. doi: 10.1016/j.molmet.2019.10.006.Epub 2019 Oct 31. PubMed PMID: 31918923; PubMed Central PMCID: PMC6909339.

GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA-dependent mechanism.

Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM. J Steroid Biochem Mol Biol. 2019 Jan;185:256-267. doi: 10.1016/j.jsbmb.2018.09.013.

Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes and regulates triglyceride accumulation and insulin sensitivity in adipocytes.

Agrawal M, Yeo CR, Shabbir A, Chhay V, Silver DL, Magkos F, Vidal-Puig A, Toh SA.

FASEB J. 2019 Jan;33(1):430-440. doi: 10.1096/fj.201701321RR.

GDF15 mediates the effects of metformin on body weight and energy balance.

Nature. 2019 Dec 25. doi: 10.1038/s41586-019-1911-y. [Epub ahead of print] Erratum in: Nature. 2020 Feb 13; PubMed PMID: 31875646.

Angiotensin-(1-7)induces beige fat thermogenesis through the Mas receptor.

Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I,Schcolnik Cabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR.

Metabolism. 2020Feb;103:154048. doi: 10.1016/j.metabol.2019.154048. Epub 2019 Dec 13. PubMed PMID: 31843339.

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW.

Nat Metab. 2019 May;1(5):546-559. doi: 10.1038/s42255-019-0055-6. Epub 2019 Apr 22. PubMed PMID: 31602424; PubMed Central PMCID: PMC6786893.

Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms.

Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T.

Int J Mol Sci. 2019 Sep 10;20(18). pii: E4448. doi: 10.3390/ijms20184448. PubMed PMID: 31509948; PubMed Central PMCID: PMC6769670.

Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity.

Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A. Elife. 2019 Aug 16;8. pii: e47990. doi: 10.7554/eLife.47990. PubMed PMID: 31418690; PubMed Central PMCID: PMC6748830.

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue.

Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ.

J Exp Med. 2019 Sep 2;216(9):1999-2009. Epub 2019 Jun 27. doi: 10.1084/jem.20190689. PubMed PMID: 31248899; PubMed Central PMCID: PMC6719433.

Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption. Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J.

Cell Rep. 2019 Jun 11;27(11):3385-3400.e3. doi: 10.1016/j.celrep.2019.05.054. PubMed PMID: 31189119.

Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.

Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM.

FASEB J. 2019 Aug;33(8):9656-9671. Epub 2019 May 30. doi: 10.1096/fj.201900479R. PubMed PMID: 31145872.

Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge.

Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA.

Frontiers in endocrinology (Lausanne). 2019 Apr 24;10:256. doi: 10.3389/fendo.2019.00256. eCollection 2019. PubMed PMID: 31068904.

Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue. Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC.

Nature Communication. 2019 Apr 4;10(1):1546. doi: 10.1038/s41467-019-09514-1. PubMed PMID: 30948720.

Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.

Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ.

Sci Rep. 2019 Feb 27;9(1):2903. doi: 10.1038/s41598-019-39562-y. PubMed PMID: 30814564.

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans.

Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S. Cell Metab. 2019 Mar 5;29(3):707-718.e8. doi: 10.1016/j.cmet.2018.12.016.

Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity.

Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ.

Mol Metab. 2019 Feb;20:38-50. doi: 10.1016/j.molmet.2018.11.010.

Interaction between Hormone-Sensitive Lipase and ChREBP in Fat Cells Controls Insulin Sensitivity.

Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud PD, Tavernier G, Caspar-Bauguil S, Virtue S, Sramkova V, Monbrun L, Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Roffarello BM, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Michel JB, Meugnier E, Ligat L, Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris WHM, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D.

Nature Metab. 2019;1:122-146. doi: 10.1038/s42255-018-0007-6.

2018

Obesity associated metabolic complications, the second wave of the tsunami.

Vidal-Puig A, Enerback S. : 14th Key Symposium. J Intern Med. 2018 Aug 23. doi: 10.1111/joim.12828. [Epub ahead of print] PMID:30141829.

PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity.

Corrales P, Vidal-Puig A, Medina-Gómez G. Int J Mol Sci. 2018 Jul 21;19(7). pii: E2124. doi: 10.3390/ijms19072124. Review. PMID:30037087.

Brown and beige fat: From molecules to physiology and pathophysiology.

Carobbio S, Guénantin AC, Samuelson I, Bahri M, Vidal-Puig A. Biochim Biophys Acta. Mol Cell Biol Lipids. 2018 May 28. pii: S1388-1981(18)30106-9. doi: 10.1016/j.bbalip.2018.05.013. [Epub ahead of print] Review. PMID:29852279.

Samuelson I, Vidal-Puig AJ. Fed-EXosome: extracellular vesicles and cell-cell communication in metabolic regulation. Essays Biochem. 2018 May 15;62(2):165-175. doi: 10.1042/EBC20170087. Print 2018 May 15. Review. PMID:29717059

2017

Carobbio S, Guénantin AC, Vidal-Puig A. Basic and Applied Thermogenesis Research' Bridging the Gap. Trends Endocrinol Metab. 2017 Oct 27. pii: S1043-2760(17)30132-7. doi: 10.1016/j.tem.2017.10.002. [Epub ahead of print]

Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D. Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review. Adv Nutr. 2017 Sep 15;8(5):694-704. doi: 10.3945/an.117.015792. Print 2017 Sep.

Carobbio S, Pellegrinelli V, Vidal-Puig A. Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome. Adv Exp Med Biol. 2017;960:161-196. doi: 10.1007/978-3-319-48382-5_7.PMID:28585199

Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A. Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases. Prog Lipid Res. 2017 Jan 16. pii: S0163-7827(16)30033-9. doi: 10.1016/j.plipres.2017.01.002. [Epub ahead of print]

2016

Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease.

Huang-Doran I, Zhang CY, Vidal-Puig A.

Trends Endocrinol Metab. 2016 Oct 31. pii: S1043-2760(16)30128-X. doi: 10.1016/j.tem.2016.10.003. [Epub ahead of print]

Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues.
Pellegrinelli V, Carobbio S, Vidal-Puig A.

Diabetologia. 2016 Jun;59(6):1075-88. doi: 10.1007/s00125-016-3933-4.

Deriving functional beige fat from capillaries.

Pellegrinelli V, Vidal-Puig A.

Nat Med. 2016 Mar 3;22(3):234-6. doi: 10.1038/nm.4056.

2015

Vacca M, Allison M, Griffin JL, Vidal-Puig A. Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD. Semin Liver Dis. 2015 Aug;35(3):250-61..

Rodriguez-Cuenca S, Barbarroja N, Vidal-Puig A. Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity. Biochim Biophys Acta. 2015 Jan;1851(1):40-50.

2014

Peirce V, Carobbio S, Vidal-Puig A. The different shades of fat. Nature. 2014 Jun 5;510(7503):76-83. Doi: 10.1038/nature13477.

Roberts LD, West JA, Vidal-Puig A, Griffin JL. Methods for performing lipidomics in white adipose tissue. Methods Enzymol. 2014;538:211-31.

2013

Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr. 2013;60 Suppl 1:39-43.

Peirce V, Vidal-Puig A. Regulation of glucose homeostasis by brown adipose tissue. Lancet Diabetes Endocrinol. 2013 Dec;1(4):353-60. Doi: 10.1016/S2213-8587(13)70055-X.

Carobbio S, Rosen B, Vidal-Puig A. Adipogenesis: new insights into brown adipose tissue differentiation. J Mol Endocrinol. 2013 Sep 16.

Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr. 2013;60 Suppl 1:39-43.

Virtue S, Vidal-Puig A. Assessment of brown adipose tissue function. Front Physiol 4:128. doi: 10.3389/fphys.2013.00128. 2013

Whittle A, Relat-Pardo J, Vidal-Puig A. Pharmacological strategies for targeting BAT thermogenesis. Trends Pharmacol Sci 2013 Jun;34(6):347-55. doi: 10.1016/j.tips.2013.04.004. Epub 2013 May 3.

Whittle A, Vidal-Puig A. When BAT is lacking. WAT steps up. Cell Res [Epud ahead of print]. (2013)

Villarroya F, Vidal-Puig A. Beyond the Sympathetic Tone: The New Brown Fat Activators. Cell Metab [Epud ahead of print]. (2013)

Dhurandhar NV, Geurts L, Atkinson RL, Casteilla L, Clement K, Gerard P, Vijay-Kumar M, Nam JH, Nieuwdorp M, Trovato G, Sørensen TI, Vidal-Puig A, Cani PD. Harnessing the beneficial properties of adipogenic microbes for improving human health. Obes Rev 2013 May 12. doi: 10.1111/obr.12045. [Epub ahead of print] (2013)

2012

Whittle AJ, Vidal-Puig A. NPs - heart hormones that regulate brown fat? J Clin Invest. February 6. 2012.

2011

Whittle AJ, Vidal-Puig A. Physiology: Immune cells fuel the fire. Nature. December 1, 2011.

Carobbio S, Rodriguez-Cuenca S, Vidal-Puig A. Origins of metabolic complications in obesity: ectopic fat accumulation. The importance of the qualitative aspect of lipotoxicity. Curr Opin Clin Nutr Metab Care. 16 August 2011.

Virtue S, Vidal-Puig A. Nothing Iffy about HIF in the Hypothalamus. PLoS Biol. July, 2011.

Whittle AJ, López M, Vidal-Puig A. Using brown adipose tissue to treat obesity - the central issue. Trends Mol Med May 20, 2011.

Blanco Martínez de Morentin P, González CR, Saha AK, Martins L, Diéguez C, Vidal-Puig A, Tena-Sempere M, López M. Hypothalamic AMP-activated proteína kinase as a mediator of whole body energy balance. Rev Endocr Metab Disord Feb 24, 2011.

Johnson F, Mavroggiani A, Ucci M, Vidal-Puig A, Wardle J. Could increased time spent in a thermal comfort zone contribute to population increases in obesity? Obes Rev Jan 24, 2011.

2010

Varela L, Vázquez MJ, Cordido F, Nogueiras R, Vidal-Puig A, Diéguez C, López M. Ghrelin and lípido metabolismo key partners in energy balance. J Mol Endocrinol Dec 17, 2010.

Hagen RM, Rodriguez-Cuenca S, Vidal-Puig A. An allostatic control of membrane lipid composition by SREBP1. FEBS Lett. 2010 Apr 9.

Vidal-Puig A, Unger RH. Special issue on lipotoxicity. Biochim Biophys Acta. 2010 Mar;1801(3):207-8.

Sethi JK, Vidal-Puig A. Wnt signalling and the control of cellular metabolism. Biochem J. 2010 Mar 15;427(1):1-17.

Virtue S, Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the Metabolic Syndrome--an allostatic perspective. Biochim Biophys Acta. 2010 Mar;1801(3):338-49

Sørensen TI, Virtue S, Vidal-Puig A. Obesity as a clinical and public health problem: is there a need for a new definition based on lipotoxicity effects? Biochim Biophys Acta. 2010 Mar;1801(3):400-4.