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The TVP Lab at the Príncipe Felipe Research Centre (CIPF) in Valencia is a collaborative research unit established through a partnership between CIPF and the University of Cambridge. Co-led by Professor Antonio Vidal-Puig and Dr. Deborah Burks, the lab focuses on investigating new therapies for metabolic diseases such as obesity, diabetes, and related complications. Located within CIPF’s cutting-edge facilities, the lab aims to drive high-impact basic research, attract international scientific talent, and strengthen CIPF’s global reputation in metabolic research. Key team members include Dr. Luke Noon and Dr. Stefania Carobbio, supported by the Generalitat Valenciana’s GenT talent program.
TVP Lab & Collaborator's Lab at CIPF :
Our research program investigates the molecular mechanisms involved in the control of energy expenditure, fat deposition, and the mechanisms that control energy partitioning toward oxidation or storage. The questions we seek to answer are:
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How the expansion of adipose tissue relates to the development of Metabolic Syndrome.
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How lipotoxicity and/or changes in adipokines secreted by adipose tissue affect insulin sensitivity in other organs such as skeletal muscle, heart, liver, brain, beta cells, and macrophages.
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Whether modifications in adipogenesis and adipose tissue remodeling may be good strategies to improve the metabolic effects associated with obesity.
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The molecular mechanisms that control energy expenditure and brown fat activation.
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Whether modulating nutrient partitioning toward fatty acid oxidation in skeletal muscle and away from storage in adipose tissue can prevent the devastating metabolic effects of obesity.
Addressing these challenges is a daunting task that requires the modulation of highly integrated and complex energy homeostasis mechanisms designed to prevent negative energy balances. In line with this integrated concept of energy homeostasis, my lab is using an Integrated Physiology approach that relies heavily on the generation and detailed in vivo phenotyping of genetically modified organisms. Along with a Systems Biology approach that integrates transcriptomic and lipidomic analysis, using bioinformatics to identify organ-specific lipid metabolic networks relevant to insulin resistance and metabolic diseases.
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Eduardo Primo Yúfera, 3 – 46012 Valencia (SPAIN)
Tel: +34 96 328 96 80
