2025
Distinct signalling dynamics of BMP4 and BMP9 in brown versus white adipocytes
Constant B, Kamzolas I, Yang X, Guo J, Rodriguez-Fdez S, Mali I, Rodriguez-Cuenca S, Petsalaki E, Vidal-Puig A, Li W
Sci Rep · 15(1):15971 · 2025
Loss of RET-ROS at complex I induces diastolic dysfunction in mice that is reversed by aerobic exercise
Vujic A, Koo A, Bidault G, Miljkovic JL, James AM, Dannhorn A, Duan X, Davis LM, Abe J, Valadares J, Lee JJ, Diaz-Vegas A, Turner K, Goodwin R, Fazakerley DJ, Vidal Puig A, Murphy MP, Krieg T
Am J Physiol Heart Circ Physiol · 2025
Oxidised Apolipoprotein Peptidome Characterises Metabolic Dysfunction-Associated Steatotic Liver Disease
Mocciaro G, George AL, Allison M, Frontini M, Huang-Doran I, Reiman F, Gribble F, Griffin JL, Vidal-Puig A, Azzu V, Kay R, Vacca M
Liver Int · 45(2):e16200 · 2025
Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice
Luk C, Bridge KI, Warmke N, Simmons KJ, Drozd M, Moran A, MacCannell ADV, Cheng CW, Straw S, Scragg JL, Smith J, Ozber CH, Wilkinson CG, Skromna A, Makava N, Prag HA, Simon Futers T, Brown OI, Bruns AF, Walker AM, Watt NT, Mughal R, Griffin KJ, Yuldasheva NY, Limumpornpetch S, Viswambharan H, Sukumar P, Beech DJ, Vidal-Puig A, Witte KK, Murphy MP, Hartley RC, Wheatcroft SB, Cubbon RM, Roberts LD, Kearney MT, Haywood NJ
Nat Commun · 16(1):170 · 2025
Clinical staging to guide management of metabolic disorders and their sequelae: a European Atherosclerosis Society consensus statement
Romeo S, Vidal-Puig A, Husain M, Ahima R, Arca M, Bhatt DL, Diehl AM, Fontana L, Foo R, Frühbeck G, Kozlitina J, Lonn E, Pattou F, Plat J, Quaggin SE, Ridker PM, Rydén M, Segata N, Tuttle KR, Verma S, Roeters van Lennep J, Benn M, Binder CJ, Jamialahmadi O, Perkins R, Catapano AL, Tokgözoğlu L, Ray KK; European Atherosclerosis Society Consensus
Eur Heart J · 2025
Decoding the Liver-Heart Axis in Cardiometabolic Diseases
Capone F, Vacca A, Bidault G, Sarver D, Kaminska D, Strocchi S, Vidal-Puig A, Greco CM, Lusis AJ, Schiattarella GG
Circ Res · 136(11):1335-1362 · 2025
Μetabolic dysfunction-associated steatotic liver disease: a condition of heterogeneous metabolic risk factors, mechanisms and comorbidities requiring holistic treatment
Byrne CD, Armandi A, Pellegrinelli V, Vidal-Puig A, Bugianesi E
Nat Rev Gastroenterol Hepatol · 22(5):314-328 · 2025
2024
Systemic analysis of lipid metabolism from individuals to multi-organism systems
Furse S, Martel C, Willer DF, Stabler D, Fernandez-Twinn DS, Scott J, Patterson-Cross R, Watkins AJ, Virtue S, Prescott TAK, Baker E, Chennells J, Vidal-Puig A, Ozanne SE, Kite GC, Vítová M, Chiarugi D, Moncur J, Koulman A, Wright GA, Snowden SG, Stevenson PC
Mol Omics · 20(9):570-583 · 2024
The role of brown adipose tissue in branched-chain amino acid clearance in people
Abdelhafez YG, Wang G, Li S, Pellegrinelli V, Chaudhari AJ, Ramirez A, Sen F, Vidal-Puig A, Sidossis LS, Klein S, Badawi RD, Chondronikola M
iScience · 27(8):110559 · 2024
Cystathionine γ-lyase-derived H2S negatively regulates thymic egress via allosteric inhibition of sphingosine-1-phosphate lyase
Hu YT, Liu ZW, Zhang TH, Ma YE, He L, Zhang J, Zhou YY, Vidal-Puig A, Pan DJ, Wu F
Acta Pharmacol Sin · 2024
SMIM1 absence is associated with reduced energy expenditure and excess weight
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE, Burden F, Farrow S; DBDS Genetic Consortium; Chen J; MAGIC; Võsa U, Burling K, Walker L, Ord J, Barker P, Warner J, Frary A, Renhstrom K, Ashford SE, Piper J, Biggs G, Erber WN, Hoffman GJ, Schoenmakers N, Erikstrup C, Rieneck K, Dziegiel MH, Ullum H, Azzu V, Vacca M, Aparicio HJ, Hui Q, Cho K, Sun YV, Wilson PW, Bayraktar OA, Vidal-Puig A, Ostrowski SR, Astle WJ, Olsson ML, Storry JR, Pedersen OB, Ouwehand WH, Chatterjee K, Vuckovic D, Frontini M
Med · 2024
The strategy behind one of the most successful labs in the world (2024) Nature 2024 Jun;630(8018):813-816
Gebel L, Velu C, Vidal-Puig A
2024 ·
A Vidal-Puig
I Kamzolas, M Vacca, L Mørch Harder, S Rodriguez-Cuenca, L Tiniakos, ..
An unbiased ranking of murine dietary models based on their proximity to human Metabolic Dysfunction–associated Steatotic Liver Disease (MASLD). Nat Metab · 2024
Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring, leading to altered fatty acid sensing and increased intake of high-fat food
Dearden L, Furigo IC, Pantaleão LC, Wong LWP, Fernandez-Twinn DS, de Almeida-Faria J, Kentistou KA, Carreira MV, Bidault G, Vidal-Puig A, Ong KK, Perry JRB, Donato J Jr, Ozanne SE
PLoS Biol · 22(6):e3002641 · 2024
Tissue-specific inflammation and insulin sensitivity in subjects with obesity
SM Oussaada, M Kilicarslan, BA de Weijer, PW Gilijamse, A Şekercan, S Virtue, IMC Janssen, A van de Laar, A Demirkiran, BA van Wagensveld, APJ Houdijk, A Jongejan, PD Moerland, J Verheij, TB Geijtenbeek, VW Bloks, MC de Goffau, JA Romijn, M Nieuwdorp, A Vidal-Puig, KW Ter Horst, MJ Serlie
Diabetes Res Clin Pract · 211:111663 · 2024
Limited oxygen in standard cell culture alters metabolism and function of differentiated cells
Tan J, Virtue S, Norris DM, Conway OJ, Yang M, Bidault G, Gribben C, Lugtu F, Kamzolas I, Krycer JR, Mills RJ, Liang L, Pereira C, Dale M, Shun-Shion AS, Baird HJ, Horscroft JA, Sowton AP, Ma M, Carobbio S, Petsalaki E, Murray AJ, Gershlick DC, Nathan JA, Hudson JE, Vallier L, Fisher-Wellman KH, Frezza C, Vidal-Puig A*, Fazakerley DJ
EMBO J · 2024
Conjugating uncoupler compounds with hydrophobic hydrocarbon chains to achieve adipose tissue selective drug accumulation
Ng MY, Song ZJ, Venkatesan G, Rodriguez-Cuenca S, West JA, Yang S, Tan CH, Ho PC, Griffin JL, Vidal-Puig A, Bassetto M, Hagen T
T. Sci Rep · 14(1):4932 · 2024
Dysfunction of Akt/FoxO3a/Atg7 regulatory loop magnifies obesity-regulated muscular mass decline
Yu Y, Yang J, Zheng L, Su H, Cao S, Jiang X, Liu X, Liu W, Wang Z, Meng F, Xu H, Wen D, Sun C, Song X, Vidal-Puig A, Cao L
Mol Metab · 81:101892 · 2024
Lipid metabolism in MASLD and MASH: From mechanism to the clinic
Carli F, Della Pepa G, Sabatini S, Vidal Puig A, Gastaldelli A
JHEP Rep · 6(12):101185 · 2024
Breaking barriers in obesity research: 3D models of dysfunctional adipose tissue
Contessi Negrini N, Pellegrinelli V, Salem V, Celiz A, Vidal-Puig A
Trends Biotechnol · 2024
Adipose Tissue Dysfunction Determines Lipotoxicity and Triggers the Metabolic Syndrome: Current Challenges and Clinical Perspectives
Carobbio S, Pellegrinelli V, Vidal-Puig A
Adv Exp Med Biol · 1460:231-272 · 2024
An adipocentric perspective of pancreatic lipotoxicity in diabetes pathogenesis
R Risi, AJ Vidal-Puig, G Bidault
Journal of Endocrinology 2024 May 15;262(1):e230313 · 2024
2023
Cold-activated brown fat-derived extracellular vesicle-miR-378a-3p stimulates hepatic gluconeogenesis in male mice
Xu J, Cui L, Wang J, Zheng S, Zhang H, Ke S, Cao X, Shi Y, Li J, Zen K, Vidal-Puig A*, Zhang CY, Li L, Jiang X
Nat Commun · 14(1):5480 · 2023
Lipidome Profiling in Childhood Obesity Compared to Adults: A Pilot Study
Soria-Gondek A, Fernández-García P, González L, Reyes-Farias M, Murillo M, Valls A, Real N, Pellitero S, Tarascó J, Jenkins B, Galán M, Villarroya F, Koulman A, Corrales P, Vidal-Puig A, Cereijo R, Sánchez-Infantes D
Nutrients · 15(15):3341 · 2023
Defective extracellular matrix remodelling in brown adipose tissue is associated with fibro-inflammation and reduced diet-induced thermogenesis
Pellegrinelli V, Figueroa-Juárez E, Samuelson I, U-Din M, Rodriguez-Fdez S, Virtue S, Leggat J, Çubuk C, Peirce VJ, Niemi T, Campbell M, Rodriguez-Cuenca S, Blázquez JD, Carobbio S, Virtanen KA, Vidal-Puig A*
Cell Rep · 42(6):112640 · 2023
Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis
Mózes FE, Lee JA, Vali Y, Alzoubi O, Staufer K, Trauner M, Paternostro R, Stauber RE, Holleboom AG, van Dijk AM, Mak AL, Boursier J, de Saint-Loup M, Shima T, Bugianesi E, Gaia S, Armandi A, Shalimar, Lupșor-Platon M, Wong VW, Li G, Wong GL, Cobbold J, Karlas T, Wiegand J, Sebastiani G, Tsochatzis E, Liguori A, Yoneda M, Nakajima A, Hagström H, Akbari C, Hirooka M, Chan WK, Mahadeva S, Rajaram R, Zheng MH, George J, Eslam M, Petta S, Pennisi G, Viganò M, Ridolfo S, Aithal GP, Palaniyappan N, Lee DH, Ekstedt M, Nasr P, Cassinotto C, de Lédinghen V, Berzigotti A, Mendoza YP, Noureddin M, Truong E, Fournier-Poizat C, Geier A, Martic M, Tuthill T, Anstee QM, Harrison SA, Bossuyt PM, Pavlides M; LITMUS investigators
Lancet Gastroenterol Hepatol · 2023
Adipose tissue plasticity in pheochromocytoma patients suggests a role of the splicing machinery in human adipose browning
Castellá M, Blasco-Roset A, Peyrou M, Gavaldà-Navarro A, Villarroya J, Quesada-López T, Lorente-Poch L, Sancho J, Szymczak F, Piron A, Rodríguez-Fernández S, Carobbio S, Goday A, Domingo P, Vidal-Puig A, Giralt M, Eizirik DL, Villarroya F, Cereijo R
iScience · 26(6):106847 · 2023
Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits adipocyte differentiation and thermogenesis
Amin A, Badenes M, Tüshaus J, de Carvalho É, Burbridge E, Faísca P, Trávníčková K, Barros A, Carobbio S, Domingos PM, Vidal-Puig A, Moita LF, Maguire S, Stříšovský K, Ortega FJ, Fernández-Real JM, Lichtenthaler SF, Adrain C
Mol Metab · 73:101731 · 2023
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)
Mocciaro G, Allison M, Jenkins B, Azzu V, Huang-Doran I, Herrera-Marcos LV, Hall Z, Murgia A, Susan D, Frontini M, Vidal-Puig A, Koulman A, Griffin JL, Vacca M
Mol Metab · 73:101728 · 2023
Machine learning algorithm improves detection of NASH (NAS-based) and at-risk NASH, a development and validation study
Lee J, Westphal M, Vali Y, Boursier J, Ostroff R, Alexander L, Chen Y, Fournier C, Geier A, Francque S, Wonders K, Tiniakos D, Bedossa P, Allison M, Papatheodoridis G, Cortez-Pinto H, Pais R, Dufour JF, Leeming DJ, Harrison S, Cobbold J, Holleboom AG, Yki-Järvinen H, Crespo J, Ekstedt M, Aithal GP, Bugianesi E, Romero-Gomez M, Karsdal M, Yunis C, Schattenberg JM, Schuppan D, Ratziu V, Brass C, Duffin K, Zwinderman K, Pavlides M, Anstee QM, Bossuyt PM; LITMUS investigators
Hepatology · 2023
Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons
Wu Q, Wu J, Karim K, Chen X, Wang T, Iwama S, Carobbio S, Keen P, Vidal-Puig A, Kotter MR, Bassett A
Mol Cell · 2023
CBL/CAP Is Essential for Mitochondria Respiration Complex I Assembly and Bioenergetics Efficiency in Muscle Cells
Aye CC, Hammond DE, Rodriguez-Cuenca S, Doherty MK, Whitfield PD, Phelan MM, Yang C, Perez-Perez R, Li X, Diaz-Ramos A, Peddinti G, Oresic M, Vidal-Puig A, Zorzano A, Ugalde C, Mora S
Int J Mol Sci · 24(4):3399 · 2023
RNAkines are secreted messengers shaping health and disease
Li J, Fang J, Jiang X, Zhang Y, Vidal-Puig A, Zhang CY
Trends Endocrinol Metab · 2023
Fuelling the fire: de novo lipogenesis primes thermogenesis
Rodríguez-Fdez S, Vidal-Puig A
Nat Metab · 5(10):1646-1648 · 2023
Differentiation of Human Pluripotent Stem Cells (hPSCs) into Brown-Like Adipocytes
Carobbio S, Vidal-Puig A
Methods Mol Biol · 2662:1-9 · 2023
Recent developments in adipose tissue-secreted factors and their target organs
Navarro-Perez J, Vidal-Puig A, Carobbio S
Curr Opin Genet Dev · 80:102046 · 2023
Spatial metabolomics and its application in the liver
Santos A, Delgado TC, Marques V, Moncayo CR, Alonso C, Vidal-Puig A, Hall Z, Martínez-Chantar ML, Rodrigues CMP
Hepatology · 2023
An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease
Lee E, Korf H, Vidal-Puig A
J Hepatol · 2023
2022
Quantitative modelling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease
Sen P, Govaere O, Sinioja T, McGlinchey A, Geng D, Ratziu V, Bugianesi E, Schattenberg JM, Vidal-Puig A, Allison M, Cockell S, Daly AK, Hyötyläinen T, Anstee QM, Orešič M
iScience · 25(9):104949 · 2022
Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis
Sabaté-Pérez A, Romero M, Sànchez-Fernàndez-de-Landa P, Carobbio S, Mouratidis M, Sala D, Engel P, Martínez-Cristóbal P, Villena JA, Virtue S, Vidal-Puig A, Palacín M, Testar X, Zorzano A
Autophagy · 2022
Human-specific gene CT47 blocks PRMT5 degradation to lead to meiosis arrest
Li C, Feng Y, Fu Z, Deng J, Gu Y, Wang H, Wu X, Huang Z, Zhu Y, Liu Z, Huang M, Wang T, Hu S, Yao B, Zeng Y, Zhou CJ, Brown SDM, Liu Y, Vidal-Puig A, Dong Y, Xu Y
Cell Death Discov · 8(1):345 · 2022
TRIM24 is an insulin-responsive regulator of P-bodies
Wei W, Chen Q, Liu M, Sheng Y, OuYang Q, Feng W, Yang X, Ding L, Su S, Zhang J, Fang L, Vidal-Puig A, Wang HY, Chen S
Nat Commun · 13(1):3972 · 2022
Time-restricted feeding entrains long-term behavioral changes through the IGF2-KCC2 pathway
Zhai Q, Zeng Y, Gu Y, Li Z, Zhang T, Yuan B, Wang T, Yan J, Qin H, Yang L, Chen X, Vidal-Puig A, Xu Y
iScience · 25(5):104267 · 2022
https://doi.org/10.1038/s42255-022-00561-5
Pellegrinelli, V., Rodriguez-Cuenca, S., Rouault, C. Vidal-Puig A. Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance. Nat Metab 4, 476–494 (2022)
2022 ·
Dietary PUFA drives various systems-level changes in lipid metabolism
Furse S, Virtue S, Snowden SG, Vidal-Puig A, Stevenson PC, Chiarugi D, Koulman A
Mol Metab · 101457 · 2022
Proceedings of the annual meeting of the European Consortium of Lipodystrophies (ECLip) Cambridge, UK, 7-8 April 2022
Mosbah H, Akinci B, Araújo-Vilar D, Carrion Tudela J, Ceccarini G, Collas P, Farooqi IS, Fernández-Pombo A, Jéru I, Karpe F, Krause K, Maffei M, Miehle K, Oral E, Perez de Tudela N, Prieur X, Rochford J, Sanders R, Santini F, Savage DB, von Schnurbein J, Semple R, Stears A, Sorkina E, Vantyghem MC, Vatier C, Vidal-Puig A, Vigouroux C, Wabitsch M
Ann Endocrinol (Paris) · 83(6):461-468 · 2022
2021
Increased serum miR-193a-5p during non-alcoholic fatty liver disease progression: Diagnostic and mechanistic relevance
Johnson K, Leary PJ, Govaere O, Barter MJ, Charlton SH, Cockell SJ, Tiniakos D, Zatorska M, Bedossa P, Brosnan MJ, Cobbold JF, Ekstedt M, Aithal GP, Clément K, Schattenberg JM, Boursier J, Ratziu V, Bugianesi E, Anstee QM, Daly AK; LITMUS Consortium Investigators
JHEP Rep · 4(2):100409 · 2021
β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development
Rao S, Yang X, Ohshiro K, Zaidi S, Wang Z, Shetty K, Xiang X, Hassan MI, Mohammad T, Latham PS, Nguyen BN, Wong L, Yu H, Al-Abed Y, Mishra B, Vacca M, Guenigault G, Allison MED, Vidal-Puig A, Benhammou JN, Alvarez M, Pajukanta P, Pisegna JR, Mishra L
Sci Transl Med · 13(624):eabk2267 · 2021
Ma, Dale M, Carobbio S, Kaser A, Fallon PG, Saez-Rodriguez J, McKenzie ANJ and Vidal-Puig A
Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guénantin AC, Leggat J, Mahler-Araujo B, Lam BY Marcella K
SREBP1-induced fatty acid synthesis depletes macrophages antioxidant defenses to promote their alternative activation. Nat Metab · 3(9):1150-1162 · 2021
Murine neuronatin deficiency is associated with hypervariable food intake and bimodal obesity
Cimino I, Rimmington D, Tung YCL, Lawler K, Larraufie P, Kay RG, Virtue S, Lam BYH, Fagnocchi L, Ma MKL, Saudek V, Zvetkova I, Vidal-Puig A, Yeo GSH, Farooqi IS, Pospisilik JA, Gribble FM, Reimann F, O'Rahilly S, Coll AP
Sci Rep · 11(1):17571 · 2021
Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects
Rodriguez-Cuenca S, Lelliot CJ, Campbell M, Peddinti G, Martinez-Uña M, Ingvorsen C, Dias AR, Relat J, Mora S, Hyötyläinen T, Zorzano A, Oresic M, Bjursell M, Bohlooly-Y M, Lindén D and Vidal-Puig, A
FASEB J · 35(9):e21752 · 2021
Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3
Tang P, Virtue S, Goie JYG, Png CW, Guo J, Li Y, Jiao H, Chua YL, Campbell M, Moreno-Navarrete JM, Shabbir A, Fernández-Real JM, Gasser S, Kemeny DM, Yang H, Vidal-Puig A, Zhang Y
Cell Death Differ · 2021
Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis
Mózes FE, Lee JA, Selvaraj EA, Jayaswal ANA, Trauner M, Boursier J, Fournier C, Staufer K, Stauber RE, Bugianesi E, Younes R, Gaia S, Lupșor-Platon M, Petta S, Shima T, Okanoue T, Mahadeva S, Chan WK, Eddowes PJ, Newsome PN, Wong VW, de Ledinghen V, Fan J, Shen F, Cobbold JF, Sumida Y, Okajima A, Schattenberg JM, Labenz C, Kim W, Lee MS, Wiegand J, Karlas T, Yılmaz Y, Aithal GP, Palaniyappan N, Cassinotto C, Aggarwal S, Garg H, Ooi GJ, Nakajima A, Yoneda M, Ziol M, Barget N, Geier A, Tuthill T, Brosnan MJ, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators
Gut · 2021
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: a systematic review and meta-analysis
Selvaraj EA, Mózes FE, Ajmer Jayaswal AN, Zafarmand MH, Vali Y, Lee JA, Levick CK, Joseph Young LA, Palaniyappan N, Liu CH, Aithal GP, Romero-Gómez M, Brosnan MJ, Tuthill TA, Anstee QM, Neubauer S, Harrison SA, Bossuyt PM, Pavlides M; LITMUS Investigators
J Hepatol · 2021
Brown Adipose Tissue Volume and Fat Content are Positively Associated with Whole-Body Adiposity in Young Men, Not in Women
Sanchez-Delgado G, Martinez-Tellez B, Acosta FM, Virtue S, Vidal-Puig A, Gil A, Llamas-Elvira JM, Ruiz JR
Diabetes · 2021
Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
Sandovici I, Hammerle CM, Virtue S, Vivas-Garcia Y, Izquierdo-Lahuerta A, Ozanne SE, Vidal-Puig A, Medina-Gómez G, Constância M
Sci Rep · 11(1):7717 · 2021
Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signalling axis
Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts L
Nature Com 12:1-21, 2021 · 2021
Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function
Petkevicius K, Bidault G, Virtue S, Newland SA, Dale M, Dugourd A, Saez-Rodriguez J, Mallat Z, Vidal-Puig A
Mol Metab 1012-20 · 2021
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression
Azzu V, Vacca M, Kamzolas I, Hall Z, Leslie J, Carobbio S, Virtue S, Davies SE, Lukasik A, Dale, Bohlooly-Y M, Acharjee A, Lindén D, Bidault G, Petsalaki E, Griffin JL, Oakley F, Allison MED, Vidal-Puig A
Mol Metab 1012-10 · 2021
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Huang LO, Rauch A, Mazzaferro E, Preuss M, Carobbio S, Bayrak CS, Chami N, Wang Z, Schick UM, Yang N, Itan Y, Vidal-Puig A, den Hoed M, Mandrup S, Kilpeläinen TO, Loos RJF
Nat Metab · 3(2):228-243 · 2021
Unraveling the developmental roadmap toward human brown adipose tissue
Carobbio S, Guenantin AC, Bahri M, Rodriguez-Fdez S, Honig F, Kamzolas I, Samuelson I, Long K, Awad S, Lukovic D, Erceg S, Bassett A, Mendjan S, Vallier L, Rosen BS, Chiarugi D, Vidal-Puig A
Stem Cell Reports · 2021
Pancreatic β cells control glucose homeostasis via the secretion of the exosomal miR-29 family
Li J, Zhang Y, Ye Y, Li D, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A, Jiang X, Zhang CY
J Extracell Vesicles 2021 Jan;10(3):e12055 · 2021
Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation
Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A
FASEB J · 35(2):e21266 · 2021
What is the most appropriate covariate in ANCOVA when analysing metabolic rate? Nat Metab
Virtue S, Lelliott CJ, Vidal-Puig A
2021 Dec;3(12):1585 · 2021
Insulin and the last gasp of failing adipocytes
Rodriguez-Cuenca S, Vidal-Puig A
Nat Metab · 3(11):1443-1444 · 2021
Lipotoxicity: a driver of heart failure with preserved ejection fraction? Clin Sci (Lond)
Leggat J, Bidault G, Vidal-Puig A
2021 Oct 15;135(19):2265-2283 · 2021
Editorial: Brown Adipose Tissue: From Heat Production in Rodents to Metabolic Health in Humans
Chondronikola M, Bartelt A, Vidal-Puig A, Virtanen KA
Front Endocrinol (Lausanne) · 12:739065 · 2021
GTTs and ITTs in mice: simple tests, complex answers
Virtue S, Vidal-Puig A
Nat Metab · 2021
Obesity and pregnancy, the perfect metabolic storm
Corrales P, Vidal-Puig A, Medina-Gómez G
Eur J Clin Nutr · 2021
2020
Transcriptomic profiling across the nonalcoholic fatty liver disease spectrum reveals gene signatures for steatohepatitis and fibrosis
Govaere O, Cockell S, Tiniakos D, Queen R, Younes R, Vacca M, Alexander L, Ravaioli F, Palmer J, Petta S, Boursier J, Rosso C, Johnson K, Wonders K, Day CP, Ekstedt M, Orešič M, Darlay R, Cordell HJ, Marra F, Vidal-Puig A, Bedossa P, Schattenberg JM, Clément K, Allison M, Bugianesi E, Ratziu V, Daly AK, Anstee QM
Sci Transl Med · 12(572):eaba4448 · 2020
The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production
Prins D, Park HJ, Watcham S, Li J, Vacca M, Bastos HP, Gerbaulet A, Vidal-Puig A, Göttgens B, Green AR
Sci Adv · 6(48):eabd3139 · 2020
Mesenchyme-derived IGF2 is a major paracrine regulator of pancreatic growth and function
Hammerle CM, Sandovici I, Brierley GV, Smith NM, Zimmer WE, Zvetkova I, Prosser HM, Sekita Y, Lam BYH, Ma M, Cooper WN, Vidal-Puig A, Ozanne SE, Medina-Gómez G, Constância M
PLoS Genet · 16(10):e1009069 · 2020
Bone Morphogenetic Protein 8b Promotes The Progression Of Non-Alcoholic Steatohepatitis Nature Metabolism
Vacca M, Leslie J, Virtue S, Lam BYH, Govaere O, Tiniakos D, Snow S, Davies S, Petkevicius K, Tong Z, Peirce V, Nielsen MJ, Ament Z, Li W, Kostrzewski T, Leeming DJ, Ratziu V, Allison MED, Anstee QM, Griffin JL, Oakley F, Vidal-Puig A
2020 Jun;2(6):514-531 · 2020
Reply to: 'Browning capabilities of human primary adipose-derived stromal cells compared to SGBS cells' Sci Rep
Yeo CR, Agrawal M, Hoon S, Shabbir A, Shrivastava MK, Huang S, Khoo CM, Chhay V, Shabeer M, Shyong Tai E, Vidal-Puig A, Toh SA
2020 Jun 15;10(1):9634 · 2020
Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure
Kwok A, Zvetkova I, Virtue S, Luijten I, Huang-Doran I, Tomlinson P, Bulger DA, West J, Murfitt S, Griffin J, Alam R, Hart D, Knox R, Voshol P, Vidal-Puig A, Jensen J, O'Rahilly S, Semple RK
Mol Metab · 40:101020 · 2020
Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma. Hepatology 2020 May 27
Hall Z, Chiarugi D, Charidemou E, Leslie J, Scott E, Pellegrinet L, Allison M, Mocciaro G, Anstee QM, Evan GI, Hoare M, Vidal-Puig A, Oakley F, Vacca M, Griffin JL
2020 ·
Publisher Correction: Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC
Nat Commun 2020 Feb 21;11(1):1078 · 2020
Publisher Correction: GDF15 mediates the effects of metformin on body weight and energy balance
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S
Nature · 578(7796):E24 · 2020
Heredity of type 2 diabetes confers increased susceptibility to oxidative stress and inflammation
Baig S, Shabeer M, Parvaresh Rizi E, Agarwal M, Lee MH, Ooi DSQ, Chia C, Aung N, Ng G, Teo Y, Chhay V, Magkos F, Vidal-Puig A, Seet RCS, Toh SA
BMJ Open Diabetes Res Care · 8(1). pii: e000945 · 2020
Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis
Badenes M, Amin A, González-García I, Félix I, Burbridge E, Cavadas M, Ortega FJ, de Carvalho É, Faísca P, Carobbio S, Seixas E, Pedroso D, Neves-Costa A, Moita LF, Fernández-Real JM, Vidal-Puig A, Domingos A, López M, Adrain C
Mol Metab · 31:67-84 · 2020
Studying Brown Adipose Tissue in a Human in vitro Context
Samuelson I, Vidal-Puig A
Front Endocrinol (Lausanne) · 11:629 · 2020
Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease
Azzu V, Vacca M, Virtue S, Allison M, Vidal-Puig A
Gastroenterology · 2020
2019
GPER and ERα mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA-dependent mechanism
Bauzá-Thorbrügge M, Rodríguez-Cuenca S, Vidal-Puig A, Galmés-Pascual BM, Sbert-Roig M, Gianotti M, Lladó I, Proenza AM
J Steroid Biochem Mol Biol · 185:256-267 · 2019
Fat storage-inducing transmembrane protein 2 (FIT2) is less abundant in type 2 diabetes and regulates triglyceride accumulation and insulin sensitivity in adipocytes
Agrawal M, Yeo CR, Shabbir A, Chhay V, Silver DL, Magkos F, Vidal-Puig A, Toh SA
FASEB J · 33(1):430-440 · 2019
GDF15 mediates the effects of metformin on body weight and energy balance
Coll AP, Chen M, Taskar P, Rimmington D, Patel S, Tadross JA, Cimino I, Yang M, Welsh P, Virtue S, Goldspink DA, Miedzybrodzka EL, Konopka AR, Esponda RR, Huang JT, Tung YCL, Rodriguez-Cuenca S, Tomaz RA, Harding HP, Melvin A, Yeo GSH, Preiss D, Vidal-Puig A, Vallier L, Nair KS, Wareham NJ, Ron D, Gribble FM, Reimann F, Sattar N, Savage DB, Allan BB, O'Rahilly S
Nature · 2019
Angiotensin-(1-7)induces beige fat thermogenesis through the Mas receptor
Vargas-Castillo A, Tobon-Cornejo S, Del Valle-Mondragon L, Torre-Villalvazo I,Schcolnik Cabrera A, Guevara-Cruz M, Pichardo-Ontiveros E, Fuentes-Romero R,Bader M, Alenina N, Vidal-Puig A, Hong E, Torres N, Tovar AR
Metabolism · 103:154048 · 2019
4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue
Grandoch M, Flögel U, Virtue S, Maier JK, Jelenik T, Kohlmorgen C, Feldmann K, Ostendorf Y, Castañeda TR, Zhou Z, Yamaguchi Y, Nascimento EBM, Sunkari VG, Goy C, Kinzig M, Sörgel F, Bollyky PL, Schrauwen P, Al-Hasani H, Roden M, Keipert S, Vidal-Puig A, Jastroch M, Haendeler J, Fischer JW
Nat Metab · 1(5):546-559 · 2019
Diet-Induced Obese Mice and Leptin-Deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms
Lee E, Miedzybrodzka EL, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T
Int J Mol Sci · 20(18). pii: E4448 · 2019
Accelerated phosphatidylcholine turnover in macrophages promotes adipose tissue inflammation in obesity
Petkevicius K, Virtue S, Bidault G, Jenkins B, Çubuk C, Morgantini C, Aouadi M, Dopazo J, Serlie MJ, Koulman A, Vidal-Puig A
Elife · 8. pii: e47990 · 2019
A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue
Rana BMJ, Jou E, Barlow JL, Rodriguez-Rodriguez N, Walker JA, Knox C, Jolin HE, Hardman CS, Sivasubramaniam M, Szeto A, Cohen ES, Scott IC, Sleeman MA, Chidomere CI, Cruz Migoni S, Caamano J, Jorgensen HF, Carobbio S, Vidal-Puig A, McKenzie ANJ
J Exp Med · 216(9):1999-2009 · 2019
Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption
Johann K, Cremer AL, Fischer AW, Heine M, Pensado ER, Resch J, Nock S, Virtue S, Harder L, Oelkrug R, Astiz M, Brabant G, Warner A, Vidal-Puig A, Oster H, Boelen A, López M, Heeren J, Dalley JW, Backes H, Mittag J
Cell Rep · 27(11):3385-3400.e3 · 2019
Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function
Ortega FJ, Moreno-Navarrete JM, Mercader JM, Gómez-Serrano M, García-Santos E, Latorre J, Lluch A, Sabater M, Caballano-Infantes E, Guzmán R, Macías-González M, Buxo M, Gironés J, Vilallonga R, Naon D, Botas P, Delgado E, Corella D, Burcelin R, Frühbeck G, Ricart W, Simó R, Castrillon-Rodríguez I, Tinahones FJ, Bosch F, Vidal-Puig A, Malagón MM, Peral B, Zorzano A, Fernández-Real JM
FASEB J · 33(8):9656-9671 · 2019
Frontiers in endocrinology (Lausanne)
Baig S, Parvaresh Rizi E, Chia C, Shabeer M, Aung N, Loh TP, Magkos F, Vidal-Puig A, Seet RCS, Khoo CM, Toh SA.Genes Involved in Oxidative Stress Pathways Are Differentially Expressed in Circulating Mononuclear Cells Derived From Obese Insulin-Resistant and Lean Insulin-Sensitive Individuals Following a Single Mixed-Meal Challenge
2019 Apr 24; 10:256 · 2019
Enhanced β-adrenergic signalling underlies an age-dependent beneficial metabolic effect of PI3K p110α inactivation in adipose tissue
Araiz C, Yan A, Bettedi L, Samuelson I, Virtue S, McGavigan AK, Dani C, Vidal-Puig A, Foukas LC
Nature Communication · 10(1):1546 · 2019
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ
Sci Rep · 9(1):2903 · 2019
GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans
Patel S, Alvarez-Guaita A, Melvin A, Rimmington D, Dattilo A, Miedzybrodzka EL, Cimino I, Maurin AC, Roberts GP, Meek CL, Virtue S, Sparks LM, Parsons SA, Redman LM, Bray GA, Liou AP, Woods RM, Parry SA, Jeppesen PB, Kolnes AJ, Harding HP, Ron D, Vidal-Puig A, Reimann F, Gribble FM, Hulston CJ, Farooqi IS, Fafournoux P, Smith SR, Jensen J, Breen D, Wu Z, Zhang BB, Coll AP, Savage DB, O'Rahilly S
Cell Metab · 29(3):707-718.e8 · 2019
Deletion of myeloid IRS2 enhances adipose tissue sympathetic nerve function and limits obesity
Rached MT, Millership SJ, Pedroni SMA, Choudhury AI, Costa ASH, Hardy DG, Glegola JA, Irvine EE, Selman C, Woodberry MC, Yadav VK, Khadayate S, Vidal-Puig A, Virtue S, Frezza C, Withers DJ
Mol Metab · 20:38-50 · 2019
Virtue S, Sramkova V, Monbrun L, Mazars A, Zanoun M, Guilmeau S, Barquissau V, Beuzelin D, Bonnel S, Marques M, Roffarello BM, Lefort C, Fielding B, Sulpice T, Astrup A, Payrastre B, Michel JB, Meugnier E, Ligat L,Lopez F, Guillou H, Ling C, Holm C, Rabasa-Lhoret R, Saris WHM, Stich V, Arner P, Rydén M, Moro C, Viguerie N, Harms M, Hallén S, Vidal-Puig A, Vidal H, Postic C, Langin D.
Morigny P, Houssier M, Mairal A, Ghilain C, Mouisel E, Benhamed F, Masri B, Recazens E, Denechaud PD, Tavernier G, Caspar-Bauguil S,
Interaction between Hormone-Sensitive Lipase and ChREBP in Fat Cells Controls Insulin Sensitivity. Nature Metab 2019 1, 122-146 · 2019
2018
Nat Comm 2018 Nov 26;9(1):4974
Pellegrinelli V, Peirce VI, Howard L, Virtue S, Turei D, Senzacqua M, FrontiniA, Dalley JW, AR Horton AR, Bidault G, SeveriI, Whittle A, Saez-Rodriguez J, Cinti S Davie AM and A Vidal-Puig Adipocyte secreted BMP8b mediates adrenergic-induced remodelling of the neuro-vascular network in adipose tissue
2018 ·
Calcium channel CaV2.3 subunits regulate hepatic glucose production by modulating leptin-induced excitation of arcuate pro-opiomelanocortin neurons
Smith MA, Katsouri L, Virtue S, Vidal-Puig A, Ashford MLJ, Withers Dj
Cell Reports 2018 Oct 9;25(2):278-287.e4 · 2018
Transforming Growth Factor-β3 Regulates Adipocyte Number in Subcutaneous White Adipose Tissue
Petrus P, Mejhert N, Corrales P, Lecoutre S, Li Q, Maldonado E, Kulyté A, Lopez Y, Campbell M, Acosta JR, Laurencikiene J, Douagi I, Gao H, Martínez-Álvarez C, Hedén P, Spalding K, Vidal-Puig A, Medina-Gomez G, ArnerP, Rydén M
Cell Reports 2018 Oct 16;25(3):551-560.e5 · 2018
Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility
Virtue S, Petkevicius K, Moreno-Navarrete JM, Jenkins B, Hart D, Dale M, Koulman A, Fernández-Real JM, Vidal-Puig A
Cell Rep · 24(8):2005-2012.e7 · 2018
Dietary stearic acid regulates mitochondria in vivo in humans
Senyilmaz-Tiebe D, Pfaff DH, Virtue S, Schwarz KV, Fleming T, Altamura S, Muckenthaler MU, Okun JG, Vidal-Puig A, Nawroth P, Teleman AA
Nat Commun · 9(1):3129 · 2018
Hepatic steatosis risk is partly driven by increased de novo lipogenesis following carbohydrate consumption
Sanders FWB, Acharjee A, Walker C, Marney L, Roberts LD, Imamura F, Jenkins B, Case J, Ray S, Virtue S, Vidal-Puig A, Kuh D, Hardy R, Allison M, Forouhi N, Murray AJ, Wareham N, Vacca M, Koulman A, Griffin JL
Genome Biol · 19(1):79 · 2018
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates
Rodriguez-Cuenca S, Carobbio S, Barceló-Coblijn G, Prieur X, Relat J, Amat R, Campbell M, Dias AR, Bahri M, Gray SL, Vidal-Puig A
Diabetes Obes Metab · 20(10):2339-2350 · 2018
Surplus fat rapidly increases fat oxidation and insulin resistance in lipodystrophic mice
Girousse A, Virtue S, Hart D, Vidal-Puig A, Murgatroyd PR, Mouisel E, Sengenès C, Savage DB
Mol Metab · 13:24-29 · 2018
Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MTG, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S
Nat Med · 24(4):525 · 2018
Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues
Arias de la Rosa I, Escudero-Contreras A, Rodríguez-Cuenca S, Ruiz-Ponce M, Jiménez-Gómez Y, Ruiz-Limón P, Pérez-Sánchez C, Ábalos-Aguilera MC, Cecchi I, Ortega R, Calvo J, Guzmán-Ruiz R, Malagón MM, Collantes-Estevez E, Vidal-Puig A, López-Pedrera C, Barbarroja N
J Intern Med · 284(1):61-77 · 2018
Vidal-Puig A, Enerback S
"Obesity-associated metabolic complications, the second wave of the tsunami" 14th Key Symposium
J Intern Med · 2018
PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity
Corrales P, Vidal-Puig A, Medina-Gómez G
Int J Mol Sci · 19(7). pii: E2124 · 2018
Brown and beige fat: From molecules to physiology and pathophysiology
Carobbio S, Guénantin AC, Samuelson I, Bahri M, Vidal-Puig A
Biochim Biophys Acta. Mol Cell Biol Lipids · 2018
Fed-EXosome: extracellular vesicles and cell-cell communication in metabolic regulation
Samuelson I, Vidal-Puig AJ
Essays Biochem · 62(2):165-175 · 2018
2017
No metabolic effects of mustard allyl-isothiocyanate compared with placebo in men
Langeveld M, Tan CY, Soeters MR, Virtue S, Watson LP, Murgatroyd PR, Ambler GK, Vidal-Puig S, Chatterjee KV, Vidal-Puig A
Am J Clin Nutr · 106(5):1197-1205 · 2017
Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance
Martínez-Sánchez N, Seoane-Collazo P, Contreras C, Varela L, Villarroya J, Rial-Pensado E, Buqué X, Aurrekoetxea I, Delgado TC, Vázquez-Martínez R, González-García I, Roa J, Whittle AJ, Gomez-Santos B, Velagapudi V, Tung YCL, Morgan DA, Voshol PJ, Martínez de Morentin PB, López-González T, Liñares-Pose L, Gonzalez F, Chatterjee K, Sobrino T, Medina-Gómez G, Davis RJ, Casals N, Orešič M, Coll AP, Vidal-Puig A, Mittag J, Tena-Sempere M, Malagón MM, Diéguez C, Martínez-Chantar ML, Aspichueta P, Rahmouni K, Nogueiras R, Sabio G, Villarroya F, López M
Cell Metab · 26(1):212-229.e12 · 2017
Shabeer Yassin, E
Chia Rou Yeo, Madhur Agrawal, Shawn Hoon, Asim Shabbir, Manu Kunaal Shrivastava, Shiqi Huang, Chin Meng Khoo, Vanna Chhay, M
Shyong Tai, Antonio Vidal-Puig & Sue-Anne Toh. SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes. Sci Rep 2017 Jun 22;7(1):4031 · 2017
mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice
Burke LK, Darwish T, Cavanaugh AR, Virtue S, Roth E, Morro J, Liu SM, Xia J, Dalley JW, Burling K, Chua S, Vidal-Puig T, Schwartz GJ, Blouet C
Elife · 6. pii: e22848 · 2017
Phenyl-γ-valerolactones, flavan-3-ol colonic metabolites, protect brown adipocytes from oxidative stress without affecting their differentiation or function
Mele L, Carobbio S, Brindani N, Curti C, Rodriguez-Cuenca S, Bidault G, Mena P, Zanotti I, Vacca M, Vidal-Puig A, Del Rio D
Mol Nutr Food Res · 61(9) · 2017
Protein CoAlation: A Redox-Regulated Protein Modification by Coenzyme Ain Mammalian Cells
Tsuchiya Y, Peak-Chew S, Newell C, Miller-Aidoo S, Mangal S, Zhyvoloup A, Baković J, Malanchuk O, Pereira G, Kotiadis V, Szabadkai G, Duchen M, Campbell M, Rodriguez Cuenca S, Vidal-Puig A, James A, Murphy MP, Filonenko V, Skehel M, Gout I
Biochem J · 474(14):2489-2508 · 2017
Lipid zonation and phospholipid remodelling in non-alcoholic fatty liver disease
Hall Z, Bond NJ, Ashmore T, Sanders F, Ament Z, Wang X, Murray AJ, Bellafante E, Virtue S, Vidal-Puig A, Allison M, Davies SE, Koulman A, Vacca M, Griffin JL
Hepatology · 65(4):1165-1180 · 2017
Basic and Applied Thermogenesis Research' Bridging the Gap
Carobbio S, Guénantin AC, Vidal-Puig A
Trends Endocrinol Metab · 2017
Dietary (Poly)phenols, Brown Adipose Tissue Activation, and Energy Expenditure: A Narrative Review
Mele L, Bidault G, Mena P, Crozier A, Brighenti F, Vidal-Puig A, Del Rio D
Adv Nutr · 8(5):694-704 · 2017
Adipose Tissue Function and Expandability as Determinants of Lipotoxicity and the Metabolic Syndrome
Carobbio S, Pellegrinelli V, Vidal-Puig A
Adv Exp Med Biol · 960:161-196 · 2017
Sphingolipids and glycerophospholipids - The "ying and yang" of lipotoxicity in metabolic diseases
Rodriguez-Cuenca S, Pellegrinelli V, Campbell M, Oresic M, Vidal-Puig A
Prog Lipid Res · 2017
2016
Meal rich in carbohydrate but not protein or fat reveals adverse immunometabolic responses associated with obesity
Parvaresh Rizi E, Baig S, Shabeer M, Teo Y, Mok SF, Loh TP, Magkos F, Virtue S, Vidal-Puig A, Tai ES, Khoo CM, Toh SA
Nutr J · 15(1):100 · 2016
Nutr Metab (Lond)
Baig S, Parvaresh Rizi E, Shabeer M, Chhay V, Mok SF, Loh TP, Magkos F, Vidal-Puig A, Tai ES, Khoo CM, Toh SA.Metabolic gene expression profile in circulating mononuclear cells reflects obesity-associated metabolic inflexibility
2016 Oct 27;13:74 · 2016
Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes
Rodriguez-Cuenca S, Whyte L, Hagen R, Vidal-Puig A, Fuller M
PLoS One · 11(9):e0162047 · 2016
Assessment of plasma acylcarnitines before and after weight loss in obese subjects
Schooneman MG, Napolitano A, Houten SM, Ambler GK, Murgatroyd PR, Miller SR, Hollak CE, Tan CY, Virtue S, Vidal-Puig A, Nunez DJ, Soeters MR
Arch Biochem Biophys · 606:73-80 · 2016
Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Morton NM, Beltram J, Carter RN, Michailidou Z, Gorjanc G, McFadden C, Barrios-Llerena ME, Rodriguez-Cuenca S, Gibbins MT, Aird RE, Moreno-Navarrete JM, Munger SC, Svenson KL, Gastaldello A, Ramage L, Naredo G, Zeyda M, Wang ZV, Howie AF, Saari A, Sipilä P, Stulnig TM, Gudnason V, Kenyon CJ, Seckl JR, Walker BR, Webster SP, Dunbar DR, Churchill GA, Vidal-Puig A, Fernandez-Real JM, Emilsson V, Horvat S
Nat Med · 22(7):771-9 · 2016
Erratum: Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance
Tan CY, Virtue S, Murfitt S, Roberts LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A
Sci Rep · 6:23873 · 2016
Cdkn1c Boosts the Development of Brown Adipose Tissue in a Murine Model of Silver Russell Syndrome
Van De Pette M, Tunster SJ, McNamara GI, Shelkovnikova T, Millership S, Benson L, Peirson S, Christian M, Vidal-Puig A, John RM
PLoS Genet · 12(3):e1005916 · 2016
Chronic subordination stress selectively downregulates the insulin signalling pathway in liver and skeletal muscle but not in adipose tissue of male mice
Sanghez V, Cubuk C, Sebastián-Leon P, Carobbio S, Dopazo J, Vidal-Puig A, Bartolomucci A
Stress · 2016
Mitochondria are required for pro-ageing features of the senescent phenotype
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF
EMBO J · 2016
Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease
Huang-Doran I, Zhang CY, Vidal-Puig A
Trends Endocrinol Metab · 2016
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli V, Carobbio S, Vidal-Puig A
Diabetologia · 59(6):1075-88 · 2016
Deriving functional beige fat from capillaries
Pellegrinelli V, Vidal-Puig A
Nat Med · 22(3):234-6 · 2016
2015
Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis
Razzoli M, Frontini A, Gurney A, Mondini E, Cubuk C, Katz LS, Cero C, Bolan PJ, Dopazo J, Vidal-Puig A, Cinti S, Bartolomucci A
Mol Metab · 5(1):19-33 · 2015
Adipose tissue fatty acid chain length and mono-unsaturation increases with obesity and insulin resistance
Yew Tan C, Virtue S, Murfitt S, Robert LD, Phua YH, Dale M, Griffin JL, Tinahones F, Scherer PE, Vidal-Puig A
Sci Rep · 5:18366 · 2015
Brown Adipose Tissue Thermogenic Capacity Is Regulated by Elovl6
Tan CY, Virtue S, Bidault G, Dale M, Hagen R, Griffin JL, Vidal-Puig A
Cell Rep · 13(10):2039-47 · 2015
Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet
Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T
Sci Rep · 5:17565 · 2015
Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans
Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A*, Bujo H*
Nat Commun · 6:8951 · 2015
Proc Natl Acad Sci U S A
Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, Jaeger D, Preiss-Landl K, Lord CC, Brown JM, Haemmerle G, Zimmermann R, Vidal-Puig A, Zechner R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity
2015 Nov 10;112(45):13850-5 · 2015
Regulation of mitochondrial morphology and function by stearoylation of TFR1
Senyilmaz D, Virtue S, Xu X, Tan CY, Griffin JL, Miller AK, Vidal-Puig A, Teleman AA
Nature · 525(7567):124-8 · 2015
Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation
Moreno-Navarrete JM, Escoté X, Ortega F, Camps M, Ricart W, Zorzano A, Vendrell J, Vidal-Puig A, Fernández-Real JM
Diabetologia · 58(10):2424-34 · 2015
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behaviour in Mice
Smith MA, Katsouri L, Irvine EE, Hankir MK, Pedroni SM, Voshol PJ, Gordon MW, Choudhury AI, Woods A, Vidal-Puig A, Carling D, Withers DJ
Cell Rep · 11(3):335-43 · 2015
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans
Virtue S, Masoodi M, de Weijer BA, van Eijk M, Mok CY, Eiden M, Dale M, Pirraco A, Serlie MJ, Griffin JL, Vidal-Puig A
Int J Obes (Lond) · 39(7):1151-60 · 2015
Human adipocytes induce inflammation and atrophy in muscle cells during obesity
Pellegrinelli V, Rouault C, Rodriguez-Cuenca S, Albert V, Edom-Vovard F, Vidal-Puig A, Clément K, Butler-Browne G, Lacasa D
Diabetes · 2015
Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation
Patel MN, Bernard WG, Milev NB, Cawthorn WP, Figg N, Hart D, Prieur X, Virtue S, Hegyi K, Bonnafous S, Bailly-Maitre B, Chu Y, Griffin JL, Mallat Z, Considine RV, Tran A, Gual P, Takeuchi O, Akira S, Vidal-Puig A, Bennett MR, Sethi JK
Proc Natl Acad Sci U S A · 112(2):506-11 · 2015
Transducin-like enhancer of split 3 (TLE3) in adipose tissue is increased in situations characterized by decreased PPARγ gene expression
Ortega FJ, Serrano M, Rodriguez-Cuenca S, Moreno-Navarrete JM, Gómez-Serrano M, Sabater M, Rodriguez-Hermosa JI, Xifra G, Ricart W, Peral B, Vidal-Puig A, Fernández-Real JM
J Mol Med (Berl) · 93(1):83-92 · 2015
Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD
Vacca M, Allison M, Griffin JL, Vidal-Puig A
Semin Liver Dis · 35(3):250-61 · 2015
Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity
Rodriguez-Cuenca S, Barbarroja N, Vidal-Puig A
Biochim Biophys Acta · 1851(1):40-50 · 2015
